Publications

Moradi M., Mousavi A., Emamgholipour Z., Giovannini J., Moghimi S., Peytam F., Honarmand A., Bach S.* and Foroumadi A.* 2023. Quinazoline-based VEGFR-2 inhibitors as potential anti-angiogenic agents: A contemporary perspective of SAR and molecular docking studies. European Journal of Medicinal Chemistry, Vol 259, 115626, https://doi.org/10.1016/j.ejmech.2023.115626.

Ribeiro E. Silva A., Diallo M.-A., Sausset A., Robert T., Bach S., Bussière F.I., Laurent F., Lacroix-Lamandé S. and Silvestre A. 2023. Overexpression of Eimeria tenella Rhoptry Kinase 2 Induces Early Production of Schizonts. Microbiology Spectrum. DOI: https://doi.org/10.1128/spectrum.00137-23.

Jabeur R., Corbel C., Loyer P., Le Parc A., Le Grand A., Comte A., Bach S., André-Leroux G., Sire O., Ben Mansour H. and Le Tilly V. 2023. Identification of Novel Compounds Inhibiting the Kinase Activity of the CDK5/p25 Complex via Direct Binding to p25. Biochemistry. Apr 19. doi: 10.1021/acs.biochem.2c00691. Online ahead of print. PMID: 37074084

Cormier P., Boutet A., Colas P., Ruchaud S., Bach S., Thomas W., Egée S., Morales J. and Roch F. 2023. The Roscoff Biological Station in the era of cellular and molecular biology: Focus on the 50 last years of research on marine animals. Cah. Biol. Mar. (2023) 64: 35-52. DOI: 10.21411/CBM.A.C705BF49

M. Hasyeoui M., Lassagne F., Erb W., Nael M., Elokely K.M., Chaikuad A., Knapp S., Jorda A., Vallés S.L., Quissac E., Verreault M., Robert T., Bach S., Samarat A., Mongin F. 2023. Oxazolo[5,4–f]quinoxaline-type selective inhibitors of glycogen synthase kinase-3α (GSK-3α): Development and impact on temozolomide treatment of glioblastoma cells, Bioorganic Chemistry (2023), doi: https://doi.org/10.1016/j.bioorg.2023.106456

Hasanvand Z., Bakhshaiesh T.O., Peytam F., Firoozpour L., Hosseinzadeh E., Motahari R., Moghimi S., Nazeri E., Toolabi M., Momeni F., Bijanzadeh H., Khalaj A., Baratte B., Josselin B., Robert T., Bach S., Esmaeili R., Foroumadi A. 2023. Imidazo[1,2-a]quinazolines as novel, potent EGFR-TK inhibitors: design, synthesis, bioactivity evaluation, and in silico studies. Bioorganic Chemistry. https://doi.org/10.1016/j.bioorg.2023.106383

Mast N., Erb W., Nauton L., Moreau P., Mongin O., Roisnel T., Macaigne M., Robert T., Bach S., Picot L., Thiéry V., J.-P. Hurvois and Mongin F. 2023. From benzofuro-, benzothieno- and 10-methylindolo-[2,3-b]-fused benzothiopyrano[4,3,2-de]quinolines to the corresponding benzothiopyrano[4,3,2-de]1,8-naphthyridines: synthesis and properties of these hexacyclic heteroaromatic compounds. New J. Chem., 2023, 47, 258. https://doi.org/10.1039/d2nj04567b

Dhiabi M., Bouattour A., Fakhfakh M., Abid S., Paquin L., Robert T., Bach S., Bazureau J-P. and Ammar H. 2023. Practical approach to N-benzyl derivatives of 2-amino-8-methoxy-4H-chromene-3-carbonitrile by reductive amination: Exploration of their effects against protein kinases and in silico ADME profiling. Journal of Molecular Structure. Vol. 1274, 15 February 2023, https://doi.org/10.1016/j.molstruc.2022.134319.

Dao V.H., Ourliac-Garnier I., Logé C., McCarthy F.O., Bach S., da Silva T.G., Denevault-Sabourin C., Thiéfaine J., Baratte B., Robert T., Gouilleux F., Brachet-Botineau M., Bazin M.-A., Marchand P. 2021. Dibenzofuran Derivatives Inspired from Cercosporamide as Dual Inhibitors of Pim and CLK1 Kinases. Molecules, 26, 6572. https://doi.org/10.3390/molecules26216572.

Choudhary B. S., Sukanya, Mehta P., Bach S., Ruchaud S., Robert T., Josselin B., Filipek S., Malik R. 2021. Discovery of thiazolidin-4-one analogue as selective GSK-3β inhibitor through structure based virtual screening. Bioorganic & Medicinal Chemistry Letters. Volume 52 (128375). https://doi.org/10.1016/j.bmcl.2021.128375.

Pieterse L., Beteck R.M., Baratte B., Jesumorotia O., Robert T., Ruchaud S., Bach S., Legoabe L. J. 2021. Synthesis and biological evaluation of selected 7H-pyrrolo[2,3-d]pyrimidine derivatives as novel CDK9/CyclinT and Haspin inhibitors. Chemico-Biological Interactions. https://doi.org/10.1016/j.cbi.2021.109643.

Ahmadu, A.A., Delehouzé, C., Haruna, A., Mustapha, L., Lawal, B.A., Udobre, A., Baratte, B., Triscornia, C., Autret, A., Robert, T., Bulinski, J.C., Rousselot, M., Simoes Eugénio, M., Dimanche-Boitrel, M., Petzer, J.P., Legoabe, L.J., Bach, S. 2021. Betulin, a Newly Characterized Compound in Acacia Auriculiformis Bark, is a Multi-target Protein Kinase Inhibitor. Molecules 2021, 26, 4599. https://doi.org/10.3390/molecules26154599. This article was previously published as preprint. Preprints 2021, 2021060115 (doi: 10.20944/preprints202106.0115.v1).

Qhobosheane M., Beteck R. M., Baratte B., Robert T., Ruchaud S., Bach S., Legoabe L.J. 2021. Exploration of 7-azaindole-coumaranone hybrids and their analogues as protein kinase inhibitors. Chemico-Biological Interactions, Available online 25 April 2021, 109478. https://doi.org/10.1016/j.cbi.2021.109478

Lassagne F.*, Sims J.M., Erb W., Mongin O., Richy N., El Osmani N., Fajloun Z.*, Picot L., Thiery V., Robert T., Bach S.*, Dorcet V., Roisnel T. and Mongin F.* 2021. Thiazolo[5,4‐f]quinoxalines, oxazolo[5,4‐f]quinoxalines and pyrazino[b,e]isatins: synthesis from 6‐aminoquinoxalines and properties. Eur. J. Org. Chem. https://doi.org/10.1002/ejoc.202100362

Oyallon B., Brachet-Botineau M., Logé C., Robert T., Bach S., Ibrahim S., Raoul W., Croix C., Berthelot P., Guillon J., Pinaud N., Gouilleux F., Viaud-Massuard M-C., Denevault-Sabourin C. 2021. New Quinoxaline Derivatives as Dual Pim-1/2 Kinase Inhibitors: Design, Synthesis and Biological Evaluation. Molecules. 26(4):867. https://doi.org/10.3390/molecules26040867

Juillet C., Ermolenko L., Boyarskaya D., Baratte B., Josselin B., Nedev H., Bach S., Iorga B., Bignon J., Ruchaud S., Al-Mourabit A. 2021. From Synthetic Simplified Marine Metabolite Analogues to New Selective Allosteric Inhibitor of Aurora B Kinase. Journal of Medicinal Chemistry. 64(2), 1197-1219. https://doi.org/10.1021/acs.jmedchem.0c02064

Brahmaiah D., Bhavani A., Aparna P., Kumar N., Solhi H., Le Guevel R., Baratte B., Ruchaud S., Bach S., Jadav S., Reddy C., Roisnel T., Mosset P., Levoin N. and Grée R. 2021. Discovery of DB18, a potent inhibitor of CLK kinases with a high selectivity against DYRK1A kinase. Bioorganic & Medicinal Chemistry. DOI: https://doi.org/10.1016/j.bmc.2020.115962

Princival I., Princival J., da Silva E., Lima S., Carregos J., de Lucenaa A., Halwass F., Franc J., Ferreir L., Hernandes M., Saraiv K., Peixoto K., Baratte B., Robert T., Bach S., Gomes D., Paiva D., Marchand P., Rodrigues M. and da Silva T. 2021. Streptomyces hygroscopicus UFPEDA 3370: a valuable source of the potent cytotoxic agent nigericin and its evaluation against human colorectal cancer cells. Chemico-Biological Interactions. 333:109316. doi: 10.1016/j.cbi.2020.109316.

Bazin A., Cojean S., Pagniez F., Bernadat G., Cavé C., Ourliac-Garnier I., Nourrisson M.-R., Morgado C., Picot C., Leclercq O., Baratte B., Robert T., Späth G.F., Rachidi N., Bach S., Loiseau P.M., Le Pape P. and Marchand P. 2021. In vitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition. European Journal of Medicinal Chemistry. Available online 23 October 2020, 112956. https://doi.org/10.1016/j.ejmech.2020.112956.

Lassagne F., Duguépéroux C., Roca C., Pérez C., Martinez A., Baratte B., Robert T., Ruchaud S., Bach S., Erb W., Roisnel T. and Mongin F. 2019. From simple quinoxalines to potent oxazolo[5,4-f]quinoxaline inhibitors of glycogen-synthase kinase 3 (GSK3). 2019. Org. Biomol. Chem., DOI: 10.1039/C9OB02002K.

Nascimento da Cruz A.C., Brondani D.J., I´talo de Santana T., Oliveira da Silva L., da Oliveira Borba E.F., de Faria A.R., Ferreira Cavalcanti de Albuquerque J., Piessard S., Matos Ximenes R., Baratte B., Bach S., Ruchaud S., Bezerra Mendonça Junior F.J., Bazin M.-A., Montenegro Rabello M., Hernandes M.Z., Marchand P. and Gonçalves da Silva T. 2019. Biological Evaluation of Arylsemicarbazone Derivatives as Potential Anticancer Agents. Pharmaceuticals, 12, 169.

Mokhtari Brikci-Nigassa N., Nauton L., Moreau P., Mongin O., Duval R., Picot L., Thiéry V., Souab M., Ruchaud S., Bach S., Guevel R., Bentabed-Ababsa G., Erb W., Roisnel T., Dorcet V., Mongin F. 2019. Functionalization of 9-thioxanthone at the 1-position: from arylamino derivatives to [1]benzo(thio)pyrano[4,3,2-de]benzothieno[2,3-b]quinolines of biological interest, Bioorganic Chemistry, 103347, doi.org/10.1016/j.bioorg.2019.103347.

Nguyen TN., Feizbakhsh O., Sfecci E., Baratte B., Delehouzé C., Garcia A., Moulin C., Colas P., Ruchaud S.*, Mehiri M.*, and Bach S. * 2019. Kinase-Based Screening of Marine Natural Extracts Leads to the Identification of a Cytotoxic High Molecular Weight Metabolite from the Mediterranean Sponge Crambe tailliezi. Mar Drugs. 2019 Oct 9;17(10). pii: E569. doi: 10.3390/md17100569.

Ziane S., Mazari M.M., Safer A.M., Sad El Hachemi Amar A., Ruchaud S., Baratte B. and Bach S. 2019. Comparison between Conventional and Nonconventional Methods for the Synthesis of Some 2-Oxazolidinone Derivatives and Preliminary Investigation of Their Inhibitory Activity Against Certain Protein Kinases. Russian Journal of Organic Chemistry. July 2019, Volume 55, Issue 7 (1061–1069). doi.org/10.1134/S1070428019070248.

Khaldoun K., Safer A., Boukabcha N., Dege N., Ruchaud S., Souab M., Bach S., Chouaih A. and Saidi-Besbes S. 2019. Synthesis and evaluation of new isatin-aminorhodanine hybrids as PIM1 and CLK1 kinase inhibitors. Journal of Molecular Structure. 1192 (82-90). ISSN 0022-2860. doi.org/10.1016/j.molstruc.2019.04.122.

Zeinyeh W., Esvan Y. J., Josselin B., Baratte B., Bach S., Nauton L., Théry V., Ruchaud S., Anizon F., Giraud F. and Moreau P. 2019. Kinase inhibitions in pyrido[4,3-h] and [3,4-g]quinazolines: Synthesis, SAR and molecular modeling studies. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. doi.org/10.1016/j.bmc.2019.04.005.

Oukoloff K., Coquelle N., Bartolini M., Naldi M., Le Guevel R., Bach S., Josselin B., Ruchaud S., Catto M., Pisani L., Denora N., Iacobazzi R.M., Silman I., Sussman J.L., Buron F., Colletier J.-P., Jean L., Routier S. and Renard P.-Y. 2019. Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3. European Journal of Medicinal Chemistry, doi.org/10.1016/j.ejmech.2018.12.063.

Motuhi S.-E., Feizbakhsh O., Foll-Josselin B., Baratte B., Delehouzé C., Cousseau A., Fant X., Bulinski J.C., Payri C.E., Ruchaud S., Mehiri M.* and Bach S.* 2019. Neurymenolide A, a Novel Mitotic Spindle Poison from the New Caledonian Rhodophyta Phacelocarpus neurymenioides. Mar. Drugs, 17, 93. doi:10.3390/md17020093.

Tazarki H., Zeinyeha W., Esvana, Y.J., Snapp K., Chatterjee D., Schröder M., Joerger A. C., Khiarib J., Josselin B., Baratte B., Bach S., Ruchaud S., Anizona F., Giraud F. and Moreau P. 2019. New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis. European Journal of Medicinal Chemistry, https://doi.org/10.1016/j.ejmech.2019.01.052.

Masłyk M., Janeczko M., Martyna A., Czernik S., Tokarska-Rodak M., Chwedczuk M., Foll-Josselin B., Ruchaud S., Bach S., Demchuk O.M. and Kubiński K. 2019. The Anti-Candida albicans Agent 4-AN Inhibits Multiple Protein Kinases. Molecules, 24, 153. doi.org/10.3390/molecules24010153.

Hamza-Reguig S., Bentabed-Ababsa G.*, Domingo L.R., Ríos-Gutiérrez M., Philippot S., Fontanay S., Duval R. E.*, Ruchaud S., Bach S.*, Roisnel T.* and Mongin F.* 2017. A combined experimental and theoretical study of the thermal [3+2] cycloaddition of carbonyl ylides with activated alkenes. J. Mol. Struct. doi.org/10.1016/j.molstruc.2017.12.052.

Ahmadu A. A., Agunu A., Nguyen T-N-D., Baratte B., Foll-Josselin B., Ruchaud S., Serive B. and Bach S. 2017. Constituents of Acacia nilotica Delile with Novel Kinase inhibitory activity. Planta Medica International Open. 4: e108–e113.

Bazureau J-P., Bouattour A., Fakhfakh M., Abid S., Ammar H., Paquin L., Le Guével R., Corlu, A., Ruchaud S. and Bach S. 2017. Reactivity under Microwave Irradiation of 2-Amino 4H-chromene-3-carbonitrile as Tool for the Construction of Potential Bioactive Derivatives. In Proceedings of the 3rd Int. Electron. Conf. Med. Chem., 1–30 November 2017; Sciforum Electronic Conference Series, Vol. 3, 2017 ; doi:10.3390/ecmc-3-04709.

Delehouzé C., Leverrier-Penna S., Le Cann F., Comte A., Jacquard-Fevai M., Delalande O., Desban N., Baratte B., Gallais I., Faurez F., Bonnet MC., Hauteville M., Goekjian PG., Thuillier, R., Favreau F., Vandenabeele P., Hauet T., Dimanche-Boitrel MT*., and Bach S*. 2017. 6E11, a new highly selective inhibitor of Receptor-Interacting Protein Kinase 1, protects cells against cold hypoxia-reoxygenation injury. Sci. Rep.; 7(1):12931. doi: 10.1038/s41598-017-12788-4.

Hedidi M., Maillard J., Erb W., Lassagne F., Halauko Y. S., Ivashkevich O. A., Matulis V. E., Roisnel T., Dorcet V., Hamze M., Fajloun Z., Baratte B., Ruchaud S., Bach S.* and Bentabed-Ababsa G.* and Mongin F.* 2017. Fused systems based on 2-aminopyrimidines: synthesis combining deprotolithiation-in situ zincation with N-arylation reactions and biological properties. Eur. J. Org. Chem. 10.1002/ejoc.201701004.

Kim J., Brown C.M., Kim M. K., Burrows E. H., Bach S., Lun D. S., Falkowski P. G. 2017. The effect of cell cycle arrest on intermediate metabolism in the marine diatom Phaeodactylum tricornutum. Proc Natl Acad Sci U S A. DOI: 10.1073/pnas.1711642114.

Le Cann F., Delehouzé C., Penna-Leverrier S., Filliol A., Comte A., Delalande O., Desban N., Baratte B., Gallais I., Piquet-Pellorce C., Faurez F., Bonnet M., Mettey Y., Goekjian P., Samson M., Vandenabeele P., Bach S.* and Dimanche-Boitrel M-T.* 2017. Sibiriline, a new small chemical inhibitor of Receptor-Interacting Protein Kinase 1, prevents immune-dependent hepatitis. FEBS Journal, 284(18):3050-3068, DOI: 10.1111/febs.14176.

Ali Bouattour A., Fakhfakh M., Abid S., Paquin L., Le Guével R., Corlu A., Ruchaud S., Bach S., Ammar H. and Bazureau J.-P. 2017. Microwave-assisted practical synthesis of 4-imino-3-phenyl-3,4-dihydro-1Hchromeno[2,3-d]pyrimidine-2(5H)-thione derivatives and exploration of their biological activities. Arkivoc 2017, part iv, 291-302.

Navarri M., Bondon A., Pottier S., Bach S., Baratte B., Ruchaud S., Barbier G., Burgaud G. and Fleury Y. 2017. Bioactive metabolites from the deep subseafloor fungus Oidiodendron griseum UBOCC-A-114129. Mar. Drugs., Apr 7;15(4). pii: E111. doi: 10.3390/md15040111.

Corbel C., Sartini S., Levati E., Colas P., Maillet L., Couturier C., Montanini B.* and Bach S.* 2017. Screening for protein-protein interaction inhibitors using a Bioluminescence Resonance Energy Transfer (BRET) based assay in yeast. SLAS Discovery (formerly Journal of Biomolecular Screening), 22(6):751-759, doi:1:2472555216689530.

Sklepari M., Lougiakis N., Papastathopoulos A., Pouli N., Marakos P., Myrianthopoulos V., Robert T., Bach S., Mikros E. and Ruchaud S. 2017. Synthesis, docking study and kinase inhibitory activity of a number of new substituted pyrazolo[3,4-c]pyridines. Chem Pharm Bull (Tokyo). 65(1):66-81. doi: 10.1248/cpb.c16-00704.

Daniilides K., Lougiakis N., Evangelidis T., Kostakis I.K., Pouli N., Marakos P., Mikros E., Skaltsounis AL., Bach S., Baratte B., Ruchaud S., Karamani V., Papafotika A., Christoforidis S., Argyros O., Kouvari E. and Tamvakopoulos C. 2016. Discovery of new aminosubstituted pyrrolopyrimidines with antiproliferative activity against breast cancer cells and investigation of their effect towards the PI3Kα enzyme. Anticancer Agents Med Chem. 2017 Dec 7. [Epub ahead of print]