© W. Thomas - SBR
Le Laboratoire de Biologie Intégrative des Modèles marins est une unité de recherche interdisciplinaire (biologie/bioinformatique/chimie/écologie) qui s’intéresse à un large éventail d’organismes marins, tels que les métazoaires, les macroalgues et les bactéries, autour de trois questions de recherche fondamentale:
Quels sont les processus moléculaires et cellulaires fondamentaux impliqués dans le destin cellulaire ?
Comment les organismes marins ont-ils évolué et quels sont les acteurs moléculaires, biochimiques et métaboliques des réponses physiologiques ?
Quelles sont les fonctions biologiques et écologiques des interactions microbiennes avec les macroalgues et leur dynamique ?
Axes Thématiques
Etudes des processus moléculaires et cellulaires fondamentaux impliqués dans le destin cellulaire
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Evolution et adaptations moléculaires, biochimiques et métaboliques des organismes marins
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Dynamiques et fonctions des interactions microbiennes avec les macroalgues
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CMAR
Le Centre Mutualisé d’Appui à la Recherche (CMAR) regroupe des personnels dont la vocation est d’offrir aux différentes équipes de recherche du laboratoire un appui scientifique et technique, sur la base de compétences spécifiques.
Contact(s)
- Catherine LeblancDirectrice d'unité
Actualités
Publication scientifique
[Cell Death Discovery] Sibiriline, a novel dual inhibitor of necroptosis and ferroptosis, prevents RIPK1 kinase activity and (phospho)lipid peroxidation as a potential therapeutic strategy
Publié le 2 décembre 2025
8 équipes de recherche
Team IMMAR - Molecular Interactions with Red Algal Matrices
Red algae are ancient eukaryotes and important primary producers in coastal marine ecosystems. Some red algae have sulfated extracellular matrix (ECM) galactans: carrageenans and agars. These polymers are essential for algal biology and provide complex carbon sources for marine microbes.
Team BABIM - BActerial BIoconversion of Macroalgae
The BABIM team aims at understanding the degradation and bioconversion of macroalgal biomass by heterotrophic bacteria, a crucial step in the marine carbon cycle. We integrate environmental microbiology studies with detailed molecular characterization of isolated bacterial degraders and evaluation of their potential applications.
Team PCF - Physiology and Cell Fate
Cell differentiation and Cell death
Team AG - Algal Genetics
The Algal Genetics Group studies various aspects of brown algal biology including responses to pathogens, speciation, life cycle regulation and development
Group leaders: J. Mark Cock, Yacine Badis
Group leaders: J. Mark Cock, Yacine Badis
Team TCCD - Translation, Cell Cycle and Development
The TCCD team studies how cell cycle and development are regulated by translation mechanisms and kinases signaling, in marine metazoans and human cell lines.
Tide Associated Rhythms of Brown Algae
Our central research objective is to unravel the molecular mechanisms underlying brown algal chronobiology, with a particular focus on circasemilunar rhythms, which are tightly linked to tidal range cycles.
Team BAG - Brown Algal Glycans
The BAG team aims to understand the structure, synthesis and functions from brown algal glycans. These glycans, or polysaccharides, are of physiological importance and constitute a key resource for various uses (food, hydrocolloids and nutraceuticals). To unravel their metabolic pathways, we use genomic and biochemical approaches, along with functional studies.
Team ABIE - Algal Biology and Interactions with the Environnement
The ABIE team aims at developing integrative biology approaches on different algal and bacterial models, from the molecular scale (structure/function analyses of proteins) to the level of the whole organism (or of several organisms in interactions) in comparative physiology studies.
Publications
Fructan utilization by members of marine Gammaproteobacteria involves SusC/D-like proteins
Marie-Katherin Zühlke, Alexandra Bahr, Daniel Bartosik, Vipul Solanki, Michelle Teune, et al.. Fructan utilization by members of marine Gammaproteobacteria involves SusC/D-like proteins. The International Society of Microbiologial Ecology Journal, 2026, ⟨10.1093/ismejo/wrag030⟩. ⟨hal-05013564⟩
Functional roles of mastigonemes in Ectocarpus gamete swimming revealed by CRISPR-Cas9 mutagenesis
Minori Harada, Gang Fu, Yacine Badis, J. Mark Cock, Susana Coelho, et al.. Functional roles of mastigonemes in Ectocarpus gamete swimming revealed by CRISPR-Cas9 mutagenesis. Protoplasma, 2026, ⟨10.1007/s00709-026-02159-0⟩. ⟨hal-05494738⟩
Comparative view of DNA methylation in stramenopiles and other eukaryotes: Focus on 5-methylcytosine
Ananya Khatei, Leïla Tirichine, M Junaid Sidiq, J. Mark Cock, Alexander Juterbock. Comparative view of DNA methylation in stramenopiles and other eukaryotes: Focus on 5-methylcytosine. Algal Research - Biomass, Biofuels and Bioproducts, 2026, 94, ⟨10.1016/j.algal.2026.104551⟩. ⟨hal-05522428⟩
Permeabilization of Host Cell Membrane
Stéphane Egée, Guillaume Bouyer, Serge L y Thomas. Permeabilization of Host Cell Membrane. Encyclopedia of Malaria, Springer, New York, NY, 2026, 978-1-4614-8325-0. ⟨hal-05546171⟩
Exploration of the extracellular matrix of the red alga Chondrus crispus reveals unprecedented insights into carrageenan structures
David Ropartz, Adrien Lissarrague, Murielle Jam, Diane Jouanneau, Bastien Annic, et al.. Exploration of the extracellular matrix of the red alga Chondrus crispus reveals unprecedented insights into carrageenan structures. Carbohydrate Polymers, 2025, 348, pp.122737. ⟨10.1016/j.carbpol.2024.122737⟩. ⟨hal-04734206⟩
Estimating consensus proteomes and metabolic functions from taxonomic affiliations
Arnaud Belcour, Pauline Hamon-Giraud, Alice Mataigne, Baptiste Ruiz, Yann Le Cunff, et al.. Estimating consensus proteomes and metabolic functions from taxonomic affiliations. 2025. ⟨hal-03697249v2⟩