Créé(e) 01/04/2015 Mis à jour 04/07/2017


Rydahl MG, Kračun SK, Fangel JU, Michel G, Guillouzo A, Génicot S, Mravec J, Harholt J, Wilkens C, Motawia MS, Svensson B, Tranquet O, Ralet M-C, Jørgensen B, Domozych DS and Willats WG (2017) Monoclonal antibodies directed against starch, glycogen and ulvan polysaccharides developed using a antibody selection (BDAS) approach. Scientific Reports, in the press.

Czjzek M, Michel G (2017) Innovating glycoside hydrolase activity on a same structural scaffold. Proceedings of the National Academy of Science, 114(19):4857-4859.

Czjzek M (2017) Biochemistry: A wine-induced breakdown. Nature, 544, 45-46.

Smith SP, Bayer EA, Czjzek M. (2017) Continually emerging mechanistic complexity of the multi-enzyme cellulosome complex. Current Opinion in Structural Biology, 44:151-160.

Zhu Y, Thomas F, Larocque R, Li N, Duffieux D, Cladière L, Souchaud F, Michel G and McBride MJ. (2017) Genetic analyses unravel the crucial role of a horizontally acquired alginate lyase for brown algal biomass degradation by Zobellia galactanivorans. Environmental Microbiology 0. doi:10.1111/1462-2920.13699.

David B, Irague R, Jouanneau D, Daligault F, Czjzek M, Sanejouand YH, Tellier C. (2017) Internal water dynamics control the transglycosylation/hydrolysis balance in the agarase (AgaD) of Zobellia galactanivorans. ACS Catalysis 7(5) : 3357–3367.

Pérez-Pascual D., ALunazzi A., Magdelenat G., Rouy Z., Roulet A., Lopez-Roques C., Larocque R., Barbeyron T., Gobet A., Michel G., Bernardet JF, Duchaud E. (2017) The complete genome sequence of the fish pathogen Tenacibaculum maritimum provides new insights into virulence mechanisms. Submitted to Journal: Frontiers in Microbiology. In the press.

Salmeán AA, Duffieux D, Harholt J, Qin F, Michel G, Czjzek M, Willats WG and Hervé C. (2017) Insoluble (1→3),(1→4)-β-D-glucan is a component of cell walls in brown algae (Phaeophyceae) and is masked by alginates in tissues Scientific Reports, 7(1):2880.

Brawley SH, Blouin NA, Ficko-Blean E, Wheeler GL, Lohr M, Goodson HV, Jenkins JW, Blaby-Haash CE, Helliwell KE, Chan CX, Marriage T, Bhattacharya D, Klein AS, Badis Y, Brodie J, Cao Y, Collén J, Dittami SM, Gachon CMM, Green BR, Karpowicz S, Kim JW, Kudahl UJ, Lin S, Michel G, Mittag M, Olson BJSC, Pangilinan J, Peng Y, Qiu H, Shu S, Singer JT, Smith AG, Sprecher BN, Wagner V, Wang W, Wang Z-Y, Yan J, Yarish C, Zäuner-Riek S, Zhuang YY, Zou Y, Lindquist EA, Grimwood J, Barry K, Rokhsar DS, Schmutz J, Stiller JW, Grossman AR, Prochnik SE (2017) Thriving in a tough environment: Insights into the red algae from the genome of Porphyra umbilicalis (Bangiophyceae, Rhodophyta). Proceedings of the National Academy of Science, in the press.


Fischl R, Bertelsen K, Gaillard F, Coelho S, Michel G, Klinger M, Boyen C, Czjzek M, Hervé C. (2016) The cell wall active mannuronan C5-epimerases in the model brown alga Ectocarpus: from gene context to recombinant protein. Glycobiology. 26(9): 973-983.

Barbeyron T, Thomas F, Barbe V, Teeling H, Schenowitz C, Dossat C, Goesmann A, Leblanc C, Glöckner FO, Czjzek M, Amann R and Michel G. (2016) Habitat and taxon as driving forces of carbohydrate catabolism in marine heterotrophic bacteria: example of the model algae-associated bacterium Zobellia galactanivorans. Environmental Microbiology, 18: 4610-4627.

Barbeyron T, Brillet-Guéguen L, Carré W., Carrière C, Caron C, Czjzek M, Hoebeke M, Michel G. (2016) Matching the diversity of sulfated biomolecules: creation of a classification database for sulfatases reflecting their substrate specificity. PLOS One, 11:e0164846.

Bennke CM, Krüger K, Kappelmann L, Huang S, Gobet A, Schüler M, Barbe V, Fuchs BM, Michel G, Teeling H, Amann RI. (2016) Polysaccharide Utilization Loci of Bacteroidetes from two contrasting open ocean sites in the North Atlantic. Environmental Microbiology, 18: 4456-4470.

Hervé C, Siméon A, Jam M, Cassin A, Johnson KL, Salmeán AA, Willats WG, Doblin MS, Bacic A, Kloareg B. (2016) Arabinogalactan proteins have deep roots in eukaryotes: identification of genes and epitopes in brown algae and their role in Fucus serratus embryo development. New Phytologist. 209: 1428–1441.

Ropartz D, Giuliani A, Fanuel M, Hervé C, Czjzek M, Rogniaux H. (2016) Online Coupling of High-Resolution Chromatography with Extreme Uv Photon Activation Tandem Mass Spectrometry: Application to the Structural Investigation of Complex Glycans by Dissociative Photoionization. Analytica Chimica Acta. 933: 1-9

Torode AT, Siméon A, Marcus SE, Jam M, Le Moigne M-A, Duffieux D, Knox JP, Hervé C. (2016) Dynamics of cell wall assembly during early embryogenesis in the brown alga Fucus. Journal of Experimental Botany. 61(21): 6089-6100.

Gunnoo M, Cazade PA, Galera-Prat A, Nash MA, Czjzek M, Cieplak M, Alvarez B, Aguilar M, Karpol A, Gaub H, Carrión-Vázquez M, Bayer EA, Thompson D. (2016) Nanoscale Engineering of Designer Cellulosomes. Advanced Materials. 28(27):5619-47.

Jam M, Ficko-Blean E, Labourel A, Larocque R, Czjzek M, Michel G. (2016) Unraveling the multivalent binding of a marine family 6 carbohydrate-binding module with its native laminarin ligand. FEBS Journal, 283, 1863-1879.

Martin M, Vandermies M, Joyeux C, Martin R, Barbeyron T, Michel G, Vandenbol M. (2016) Discovering novel enzymes by functional screening of plurigenomic libraries from alga-associated Flavobacteriia and Gammaproteobacteria. Microbiological Research, 186, 52-61.

Préchoux, A., Genicot, S., Rogniaux, H., and Helbert, W. (2016). Enzyme-assisted preparation of furcellaran-like κ-/β-carrageenan. Marine Biotechnology 18, 133-143.

Olsen JL, Pierre Rouzé P, Verhelst B, Lin Y-C, Bayer T, Collén J, Dattolo E, De Paoli E, Dittami S, Maumus F, Michel G, Kersting A, Lauritano C, Lohaus R, Töpel M, Tonon T, Vanneste K, Amirebrahimi M, Brakel J, Boström C, Chovatia M, Grimwood J, Jenkins JW, Jüterbock A, Mraz A, Stam WT, Tice H, Bornberg-Bauer E, Green PJ, Pearson GA, Procaccini G, Duarte CM, Schmutz J, Reusch TBH & van de Peer Y. (2016) The genome of the seagrass Zostera marina reveals angiosperm adaptation to the sea. Nature 530: 331-335


Ficko-Blean E, Duffieux D, Rebuffet  E , Larocque R, Groisillier A, Michel G, Czjzek M. (2015) Biochemical and structural investigation of two paralogous glycoside hydrolases from Zobellia galactanivorans: novel insights into the evolution, dimerization plasticity and catalytic mechanism of the GH117 family. Acta Crystallographica Section D: Biological Crystallography, 71, 209–223. doi: 10.1107/S1399004714025024.

Labourel A, Jam M, Legentil L, Sylla B, Hehemann JH, Ferrières V, Czjzek M and Michel G (2015) Structural and biochemical characterization of the laminarinase ZgLamCGH16 from Zobellia galactanivorans suggests a preferred recognition of branched laminarin. Acta Crystallographica D71, doi:10.1107/S139900471402450X.

Różycki B, Cieplak M, Czjzek M. (2015) Large conformational fluctuations of the multi-domain Xylanase Z of Clostridium thermocellum. Journal of Structural Biology, 191(1):68-75. doi: 10.1016/j.jsb.2015.05.004.

Groisillier A, Labourel A, Michel G, Tonon T. (2015) The Mannitol Utilization. System of the Marine Bacterium Zobellia galactanivorans. Applied and Environmental Microbiology, 81, 1799–1812, doi: 10.1128/AEM.02808-14.

Torode TA, Marcus SE, Jam M, Tonon T, Blackburn RS, Hervé C, Knox JP (2015). Monoclonal Antibodies Directed to Fucoidan Preparations from Brown Algae. PLoS One, 10(2): e0118366.

Ropartz D, Giuliani A, Hervé C, Geairon A, Jam M, Czjzek C, Rogniaux H (2015). High-Energy Photon Activation Tandem Mass Spectrometry Provides Unprecedented Insights into the Structure of Highly Sulfated Oligosaccharides Extracted from Macroalgal Cell Walls. Analytical Chemistry 87(2): 1042-49.

Tsirigoti A, Beakes GW, Hervé C, Gachon CM, Katsaros C. (2015) Attachment, penetration and early host defense mechanisms during the infection of filamentous brown algae by Eurychasma dicksonii. Protoplasma: 1-12

Xing P, Hahnke RL, Unfried F, Markert S, Huang S, Barbeyron T, Harder J, Becher D, Schweder T, Glöckner FO, Amann RI, Teeling H. (2015) Niches of two polysaccharide-degrading Polaribacter isolates from the North Sea during a spring diatom bloom. ISME Journal, 9, 1410-1422.

Martin M, Barbeyron T, Martin R, Portetelle D, Michel G, Vandenbol M (2015) The cultivable surface microbiota of the brown alga Ascophyllum nodosum is enriched in macroalgal-polysaccharide-degrading bacteria. Frontiers in Microbiology, 6:1487.


Deniaud-Bouët E., Kervarec N., Michel G., Tonon T., Kloareg B., Hervé C. (2014) Chemical and enzymatic fractionation of cell walls from Fucales: insights into the structure of the extracellular matrix of brown algae. Annals of Botany, 114(6):1203–16.

Genicot SM, Groisillier A, Rogniaux H, Meslet-Cladière L, Barbeyron T, Helbert W. (2014) Discovery of a novel iota carrageenan sulfatase isolated from the marine bacterium Pseudoalteromonas carrageenovora. Frontiers in Chemistry, 2: 67

Hehemann JH, Boraston AB, Czjzek M. (2014) A sweet new wave: structures and mechanisms of enzymes that digest polysaccharides from marine algae. Current Opinion in Structural Biology, 28, 77-86.

Labourel A., M. Jam, A. Jeudy, J.-H. Hehemann, M. Czjzek, and G. Michel. (2014) The β-glucanase ZgLamA from Zobellia galactanivorans evolved a bent active site adapted for efficient degradation of algal laminarin. Journal of Biological Chemistry, 289(4):2027–42. doi: 10.1074/jbc.M113.538843.

Thomas F., Cosse A., Le Panse S., Kloareg B., Potin P., Leblanc C. (2014) Kelps feature systemic  defense responses: insights into the evolution of innate immunity in multicellular eukaryotes. New Phytologist, 204(3):567–76.

Martin M, Biver S, Steels S, Barbeyron T, Jam M, Portetelle D, Michel G, Vandenbol M (2014) Identification and characterization of a halotolerant, cold-active marine endo-β-1,4-glucanase by using functional metagenomics of seaweed-associated microbiota. Applied and Environmental Microbiology, 80, 4958-4967.

Martin M., Portetelle D., Michel G., Vandenbol M. (2014) Microorganisms living on macroalgae: diversity, interactions, and biotechnological applications. Applied Microbiology and Biotechnology, 98(7):2917–35. doi: 10.1007/s00253-014-5557-2.

Molza AE, Férey N, Czjzek M, Le Rumeur E, Hubert JF, Tek A, Laurent B, Baaden M, Delalande O. (2014) Innovative interactive flexible docking method for multi-scale reconstruction elucidates dystrophin molecular assembly. Faraday Discussions, 169:45-62.

Nyvall Collen P., Jeudy A., Sassi J.-F., Groisillier A., Czjzek M., Coutinho P. M, Helbert W. (2014) A novel unsaturated β-glucuronyl hydrolase involved in ulvan degradation unveils the versatility of stereochemistry requirements in family GH105. Journal of Biological Chemistry, 289(9):6199–211.

Teze D., Hendricks J., Czjzek M., Ropartz D., Sanejouand Y.-H., Tran V., Tellier C., Dion M. (2014) Semi-rational approach for converting a GH1 β-glycosidase into a β-transglycosidase. Protein Engineering, Design and Selection, 27(1):13–9. doi:10.1093/protein/gzt057.

Werner J, Ferrer M, Michel G, Mann AJ, Huang S, Juarez S, Ciordia S, Albar JP, Alcaide M, La Cono V, Yakimov MM, Antunes A, Taborda M, da Costa MS, Hai T, Glöckner FO, Golyshina OV, Golyshin PN, Teeling H. (2014) Halorhabdus tiamatea: Proteogenomics and glycosidase activity measurements identify the first cultivated euryarchaeon from a deep-sea anoxic brine lake as potential polysaccharide degrader. Environmental Microbiology, 16, 2525-37.

Fournier JB, Rebuffet E, Delage L, Grijol R, Meslet-Cladière L, Rzonca J, Potin P, Michel G, Czjzek M and Leblanc C (2014) The bacterial vanadium iodoperoxidase from the marine Flavobacteriaceae Zobellia galactanivorans reveals novel molecular and evolutionary features of halide specificity in this enzyme family. Applied and Environmental Microbiology, 80, 7561-7573.

Dittami SM, Barbeyron T, Boyen C, Cambefort J, Collet G, Delage L, Gobet A, Groisillier A, Leblanc C, Michel G, Scornet D, Siegel A, Tapia JE and Tonon T (2014) Genome and metabolic network of “Canditatus Phaeomarinobacter ectocarpi” Ec32, a new candidate genus of Alphaproteobacteria frequently associated to brown algae. Frontiers in Genetics, 5:241.

Kowalczyk N., Rousvoal S., Hervé C., Boyen C., Coll´en J. (2014) RT- qPCR normalization genes in the red alga Chondrus crispus. PLoS ONE, 9(2): e86574. doi: 10.1371/journal.pone.0086574.

Groisillier A, Shao Z, Michel G, Goulitquer S, Bonin P, Krahulec S, Nidetzky B, Duan D, Boyen C and Tonon T. (2014) Mannitol metabolism in brown algae involves a new phosphatase family. Journal of Experimental Botany, 65, 559-570.


Michel G and Czjzek M (2013) Polysaccharide degrading enzymes from marine bacteria. In Marine enzymes for biocatalysis. Sources, biocatalytic characteristics and bioprocesses of marine enzymes. Woodhead Publishing Limited. Edited by Antonio Trincone. pp. 429-464.

Thomas F, Lundqvist LC, Jam M, Jeudy A, Barbeyron T, Sandström C, Michel G, Czjzek M. (2013) Comparative Characterization of Two Marine Alginate Lyases from Zobellia galactanivorans Reveals Distinct Modes of Action and Exquisite Adaptation to Their Natural Substrate. Journal of Biological Chemistry, 288, 23021-23037

Ma S, Duan G, Chai W, Geng C, Tan Y, Wang L, Le Sourd F, Michel G, Yu W, Han F (2013) Purification, cloning, characterization and essential amino acid residues analysis of a new ι-carrageenase from Cellulophaga sp. QY3. PLOS One, 8, e64666.

Collén J, Porcel B, Carré W, Ball B, Chaparro C, Tonon T, Barbeyron T, Michel G, Noel B, Valentin K, Elias M, Artiguenave F, Arun A, Aury JM, Barbosa-Neto JF, Bothwell JH, Bouget FY, Brillet L, Cabello-Hurtado F, Capella-Gutíerrez S, Charrier B, Cladière L, Cock JM, Coelho SM, Colleoni C, Czjzek M, Da Silva C, Delage L, Denoeud F, Deschamps P, Dittami SM, Gabaldón T, Gachon CMM, Groisillier A, Hervé C, Jabbari K, Katinka M, Kloareg B, Kowalczyk N, Labadie K, Leblanc C, Lopez PJ, McLachlan D, Meslet-Cladiere L, Moustafa A, Nehr Z, Nyvall Collén P, Panaud O, Partensky F, Poulain J, Rensing SA, Rousvoal S, Samson G, Symeonidi A, Weissenbach J, Zambounis A, Wincker P, Boyen C (2013) Genome structure and metabolic features in the red seaweed Chondrus crispus shed light on evolution of the Archaeplastida. Proceedings of the National Academy of Science, 110, 5247-5252.

Lechauve C, Jager M, Laguerre L, Kiger L, Correc G, Leroux C, Vinogradov S, Czjzek M, Marden MC, Bailly X. (2013) Neuroglobins, pivotal proteins associated with emerging neural systems and precursors of metazoan globin diversity. Journal of Biological Chemistry, 288, 6957-6967.

Gosselin P, Martineau Y, Morales J, Czjzek M, Glippa V, Gauffeny I, Morin E, Le Corguillé G, Pyronnet S, Cormier P, Cosson B. (2013) Tracking a refined eIF4E-binding motif reveals Angel1 as a new partner of eIF4E. Nucleic Acids Research, 41, 7783-7792.

Meslet-Cladière L, Delage L, Leroux CJ, Goulitquer S, Leblanc C, Creis E, Gall EA, Stiger-Pouvreau V, Czjzek M, Potin P. (2013) Structure/Function analysis of a type iii polyketide synthase in the brown alga Ectocarpus siliculosus reveals a biochemical pathway in phlorotannin monomer biosynthesis. Plant Cell, 25, 3089-3103.

Martin M, Barbeyron T, Michel G, Daniel P, Vandenbol M. (2013) Functional screening of a metagenomic library from algal biofilms. Communications in Agricultural and Applied Biological Sciences. 78, 235-242.

Mann AJ, Hahnke RL, Huang S, Werner J, Xing P, Barbeyron T, Huettel B, Stüber K, Reinhardt R, Harder J, Glöckner FO, Amann RI, Teeling H (2013) The genome of the alga-associated marine flavobacterium Formosa agariphila KMM 3901T reveals a broad potential for degradation of algal polysaccharides. Applied and Environmental Microbiology, 79, 6813-6822.