Created 25/02/2017


Torode TA, Marcus SE, Jam M, Tonon T, Blackburn RS, Hervé C, Knox JP (2015). Monoclonal Antibodies Directed to Fucoidan Preparations from Brown Algae. PLoS One, 10(2): e0118366.

Ropartz D, Giuliani A, Hervé C, Geairon A, Jam M, Czjzek C, Rogniaux H (2015). High-Energy Photon Activation Tandem Mass Spectrometry Provides Unprecedented Insights into the Structure of Highly Sulfated Oligosaccharides Extracted from Macroalgal Cell Walls. Analytical Chemistry 87(2): 1042-49.

Kowalczyk N, Rousvoal S, Hervé C, Boyen C, Collén J (2014). RT-qPCR normalization genes in the red alga Chondrus crispus. PLoS One, 9(2): e86574.

Ficko-Blean E, Duffieux D, Rebuffet E, Larocque R, Groisillier A, Michel G and Czjzek M (2014) Biochemical and structural investigation of two paralogous glycoside hydrolases from Zobellia galactanivorans: novel insights into the evolution, dimerization plasticity and catalytic mechanism of the GH117 family. Acta Crystallographica D71, doi:10.1107/S1399004714025024.

Labourel A, Jam M, Legentil L, Sylla B, Hehemann JH, Ferrières V, Czjzek M and Michel G (2015) Structural and biochemical characterization of the laminarinase ZgLamCGH16 from Zobellia galactanivorans suggests a preferred recognition of branched laminarin. Acta Crystallographica D71, doi:10.1107/S139900471402450X.

Tsirigoti A, Beakes GW, Hervé C, Gachon CM, Katsaros C. (2015) Attachment, penetration and early host defense mechanisms during the infection of filamentous brown algae by Eurychasma dicksonii. Protoplasma: 1-12

Xing P, Hahnke RL, Unfried F, Markert S, Huang S, Barbeyron T, Harder J, Becher D, Schweder T, Glöckner FO, Amann RI, Teeling H. (2015) Niches of two polysaccharide-degrading Polaribacter isolates from the North Sea during a spring diatom bloom. ISME Journal, doi: 10.1038/ismej.2014.225. [Epub ahead of print]




Fournier JB, Rebuffet E, Delage L, Grijol R, Meslet-Cladière L, Rzonca J, Potin P, Michel G, Czjzek M and Leblanc C (2014) The bacterial vanadium iodoperoxidase from the marine Flavobacteriaceae Zobellia galactanivorans reveals novel molecular and evolutionary features of halide specificity in this enzyme family. Applied and Environmental Microbiology, 80, 7561-7573.

Dittami SM, Barbeyron T, Boyen C, Cambefort J, Collet G, Delage L, Gobet A, Groisillier A, Leblanc C, Michel G, Scornet D, Siegel A, Tapia JE and Tonon T (2014) Genome and metabolic network of “Canditatus Phaeomarinobacter ectocarpi” Ec32, a new candidate genus of Alphaproteobacteria frequently associated to brown algae. Frontiers in Genetics, 5:241.

Martin M, Biver S, Steels S, Barbeyron T, Jam M, Portetelle D, Michel G, Vandenbol M (2014) Identification and characterization of a halotolerant, cold-active marine endo-β-1,4-glucanase by using functional metagenomics of seaweed-associated microbiota. Applied and Environmental Microbiology, 80, 4958-4967.

Deniaud-Bouët E, Kervarec N, Michel G, Tonon T, Kloareg B, Hervé C (2014) Chemical and enzymatic fractionation of fucalean algal cell-walls: insights into the structure of the extra-cellular matrix of brown algae. Annals of Botany, 114, 1203-16.

Werner J, Ferrer M, Michel G, Mann AJ, Huang S, Juarez S, Ciordia S, Albar JP, Alcaide M, La Cono V, Yakimov MM, Antunes A, Taborda M, da Costa MS, Hai T, Glöckner FO, Golyshina OV, Golyshin PN, Teeling H (2014) Halorhabdus tiamatea: Proteogenomics and glycosidase activity measurements identify the first cultivated euryarchaeon from a deep-sea anoxic brine lake as potential polysaccharide degrader. Environmental Microbiology, 16, 2525-37.

Martin M, Portetelle D, Michel G, Vandenbol M (2014) Microorganisms living on macroalgae: Diversity, interactions, and biotechnological applications. Applied Microbiology and Biotechnology, 98, 2917-35.

Groisillier A, Shao Z, Michel G, Goulitquer S, Bonin P, Krahulec S, Nidetzky B, Duan D, Boyen C, Tonon T (2014) Mannitol metabolism in brown algae involves a new phosphatase family. Journal of Experimental Botany, 65, 559-570.

Labourel A, Jam M, Jeudy A, Hehemann JH, Czjzek M, Michel G (2014) The β-glucanase ZgLamA from Zobellia galactanivorans evolved a bent active site adapted for an efficient degradation of algal laminarin. Journal of Biological Chemistry, 289, 2027–2042.

Teze D, Hendrickx J, Czjzek M, Ropartz D, Sanejouand YH, Tran V, Tellier C, Dion M (2014) Semi-rational approach for converting a GH1 β-glycosidase into a β-transglycosidase. Protein Engineering, Design and Selection, 27, 13-19.
Nyvall-Collén P, Jeudy A, Sassi JF, Groisillier A, Czjzek M, Coutinho PM, Helbert W. (2014) A novel unsaturated β-glucuronyl hydrolase involved in ulvan degradation unveils the versatility of stereochemistry requirements in family GH105. Journal of Biological Chemistry, Feb 28;289(9):6199-211


Michel G and Czjzek M (2013) Polysaccharide degrading enzymes from marine bacteria. In Marine enzymes for biocatalysis. Sources, biocatalytic characteristics and bioprocesses of marine enzymes. Woodhead Publishing Limited. Edited by Antonio Trincone. pp. 429-464.

Thomas F, Lundqvist LC, Jam M, Jeudy A, Barbeyron T, Sandström C, Michel G, Czjzek M. (2013) Comparative Characterization of Two Marine Alginate Lyases from Zobellia galactanivorans Reveals Distinct Modes of Action and Exquisite Adaptation to Their Natural Substrate. Journal of Biological Chemistry, 288, 23021-23037

Ma S, Duan G, Chai W, Geng C, Tan Y, Wang L, Le Sourd F, Michel G, Yu W, Han F (2013) Purification, cloning, characterization and essential amino acid residues analysis of a new ι-carrageenase from Cellulophaga sp. QY3. PLOS One, 8, e64666.

Collén J, Porcel B, Carré W, Ball B, Chaparro C, Tonon T, Barbeyron T, Michel G, Noel B, Valentin K, Elias M, Artiguenave F, Arun A, Aury JM, Barbosa-Neto JF, Bothwell JH, Bouget FY, Brillet L, Cabello-Hurtado F, Capella-Gutíerrez S, Charrier B, Cladière L, Cock JM, Coelho SM, Colleoni C, Czjzek M, Da Silva C, Delage L, Denoeud F, Deschamps P, Dittami SM, Gabaldón T, Gachon CMM, Groisillier A, Hervé C, Jabbari K, Katinka M, Kloareg B, Kowalczyk N, Labadie K, Leblanc C, Lopez PJ, McLachlan D, Meslet-Cladiere L, Moustafa A, Nehr Z, Nyvall Collén P, Panaud O, Partensky F, Poulain J, Rensing SA, Rousvoal S, Samson G, Symeonidi A, Weissenbach J, Zambounis A, Wincker P, Boyen C (2013) Genome structure and metabolic features in the red seaweed Chondrus crispus shed light on evolution of the Archaeplastida. Proceedings of the National Academy of Science, 110, 5247-5252.

Lechauve C, Jager M, Laguerre L, Kiger L, Correc G, Leroux C, Vinogradov S, Czjzek M, Marden MC, Bailly X. (2013) Neuroglobins, pivotal proteins associated with emerging neural systems and precursors of metazoan globin diversity. Journal of Biological Chemistry, 288, 6957-6967.

Gosselin P, Martineau Y, Morales J, Czjzek M, Glippa V, Gauffeny I, Morin E, Le Corguillé G, Pyronnet S, Cormier P, Cosson B. (2013) Tracking a refined eIF4E-binding motif reveals Angel1 as a new partner of eIF4E. Nucleic Acids Research, 41, 7783-7792.

Meslet-Cladière L, Delage L, Leroux CJ, Goulitquer S, Leblanc C, Creis E, Gall EA, Stiger-Pouvreau V, Czjzek M, Potin P. (2013) Structure/Function analysis of a type iii polyketide synthase in the brown alga Ectocarpus siliculosus reveals a biochemical pathway in phlorotannin monomer biosynthesis. Plant Cell, 25, 3089-3103.

Martin M, Barbeyron T, Michel G, Daniel P, Vandenbol M. (2013) Functional screening of a metagenomic library from algal biofilms. Communications in Agricultural and Applied Biological Sciences. 78, 235-242.
Mann AJ, Hahnke RL, Huang S, Werner J, Xing P, Barbeyron T, Huettel B, Stüber K, Reinhardt R, Harder J, Glöckner FO, Amann RI, Teeling H (2013) The genome of the alga-associated marine flavobacterium Formosa agariphila KMM 3901T reveals a broad potential for degradation of algal polysaccharides. Applied and Environmental Microbiology, 79, 6813-6822.

Lowe EC, Baslé A, Czjzek M, Firbank SJ, Bolam DN (2012) A scissor blade-like closing mechanism implicated in transmembrane signaling in a Bacteroides hybrid two-component system. Proc Natl Acad Sci U S A, 109, 7298-7303.

Creze C, Ligabue A, Laurent S, Lestini R, Laptenok SP, Khun J, Vos MH, Czjzek M, Myllykallio H and Flament D (2012) Modulation of the Pyrococcus abyssi NucS endonuclease activity by replication clamp at functional and structural levels, J Biol Chem, 287, 15648-15660.

Czjzek M, Fierobe HP and Receveur-Brechot V (2012) Small-angle X-ray scattering and crystallography: a winning combination for exploring the multimodular organization of cellulolytic macromolecular complexes, Methods Enzymol, 510, 183-210.

Hehemann J-H, Correc G, Thomas F, Bernard T, Barbeyron T, Jam M, Helbert W, Michel G and Czjzek M (2012) Biochemical and structural characterization of the complex agarolytic enzyme system from the marine bacterium Zobellia galactanivorans, J Biol Chem 287, 30571-84

Lundqvist LC, Jam M, Barbeyron T, Czjzek M and Sandstrom C (2012) Substrate specificity of the recombinant alginate lyase from the marine bacteria Pseudomonas alginovora, Carbohydr Res, 352, 44-50.

Thomas F, Barbeyron T, Tonon T, Genicot S, Czjzek M and Michel G (2012) Characterization of the first alginolytic operons in a marine bacterium: from their emergence in marine Flavobacteriia to their independent transfers to marine Proteobacteria and human gut Bacteroides, Environ Microbiol, 14, 2379-94

J. Mark Cock, Lieven Sterck, Sophia Ahmed, Andrew E. Allen, Grigoris Amoutzias, Veronique Anthouard, François Artiguenave, Alok Arun, Jean-Marc Aury, Jonathan H. Badger, Bank Beszteri, Kenny Billiau, Eric Bonnet, John H. Bothwell, Chris Bowler, Catherine Boyen, Colin Brownlee, Carl J. Carrano, Bénédicte Charrier, Ga Youn Cho, Susana M. Coelho, Jonas Collén, Gildas Le Corguillé, Erwan Corre, Laurence Dartevelle, Corinne Da Silva, Ludovic Delage, Nicolas Delaroque, Simon M. Dittami, Sylvie Doulbeau, Marek Elias, Garry Farnham, Claire M.M. Gachon, Olivier Godfroy, Bernhard Gschloessl, Svenja Heesch, Kamel Jabbari, Claire Jubin, Hiroshi Kawai, Kei Kimura, Bernard Kloareg, Frithjof C. Küpper, Daniel Lang, Aude Le Bail, Rémy Luthringer, Catherine Leblanc, Patrice Lerouge, Martin Lohr, Pascal J. Lopez, Nicolas Macaisne, Cindy Martens, Florian Maumus, Gurvan Michel, Diego Miranda-Saavedra, Julia Morales, Hervé Moreau, Taizo Motomura, Chikako Nagasato, Carolyn A. Napoli, David R. Nelson, Pi Nyvall-Collén, Akira F. Peters, Cyril Pommier, Philippe Potin, Julie Poulain, Hadi Quesneville, Betsy Read, Stefan A. Rensing, Andrés Ritter, Sylvie Rousvoal, Manoj Samanta, Gaelle Samson, Declan C. Schroeder, Delphine Scornet, Béatrice Ségurens, Martina Strittmatter, Thierry Tonon, James W. Tregear, Klaus Valentin, Peter von Dassow, Takahiro Yamagishi, Pierre Rouzé, Yves Van de Peer and Patrick Wincker (2012) “The Ectocarpus Genome and Brown Algal Genomics », Advances in Botanical Research, 64 , 141-184

Correc G, Hehemann J-H, Czjzek M and Helbert W (2011), Structural analysis of the degradation products of porphyran digested by Zobellia galactanivorans β-porphyranase A, Carbohydrate Polymers, 83, 277-283

Lammerts van Bueren A, Ficko-Blean E, Pluvinage B, Hehemann J-H, Higgins MA, Deng L, Ogunniyi AD, Stroehe UHr, El Warry N, Burke RD, Czjzek M, Paton JC, Vocadlo DJ and Boraston AB (2011), The conformation and function of a multimodular glycogen-degrading pneumococcal virulence factor, Structure, 19, 640-651.

Thomas F, Hehemann J-H, Rebuffet E, Czjzek M and Michel G (2011) Environmental and gut bacteroidetes: the food connection, Front Microbiol, 2, 93.

Popper ZA, Michel G, Hervé C, Domozych D, Willats WGT, Tuohy MG, Kloareg B and Stengel DB (2011) Evolution and diversity of plant cell walls: from algae to flowering plants. Annual Review of Plant Biology, 62, 1899-1905.

Rebuffet E, Groisillier A, Thompson A, Jeudy A, Barbeyron T, Czjzek M and Michel G (2011) Discovery and structural characterization of a novel glycosidase family of marine origin. Environmental Microbiology, 13, 1253-1270.

Barbeyron T, Lerat Y, Sassi JF, Le Panse S, Helbert W and Nyvall Collén P (2011) Persicivirga ulvanivorans sp. nov., a marine Flavobacteriaceae degrading ulvan from green algae. International Journal of Systematic and Evolutionary Microbiology, 61, 1899-1905.

Corporeau C, Groisillier A, Jeudy A, Barbeyron T, Fleury E, Fabioux C, Czjzek M and Huvet A (2011) A Functional Study of Transforming Growth Factor-Beta from the Gonad of Pacific Oyster Crassostrea gigas. Marine Biotechnology, 13, 971-980.

Gosselin P, Oulhen N, Jam M, Ronzca J, Cormier P, Czjzek M and Cosson B (2011) The translational repressor 4E-BP called to order by eIF4E: new structural insights by SAXS. Nucleic Acids Research, 39, 3469-3503.

Creze C, Lestini R, Kühn J, Ligabue A, Becker HF, Czjzek M, Flament D and Myllykallio H (2011) Structure and function of a novel endonuclease acting on branched DNA substrates. Biochemical Society transactions, 39, 145-149.

Rousvoal S, Groisillier A, Dittami SM, Michel G, Boyen C and Tonon T (2011) Mannitol-1-phosphate dehydrogenase activity in Ectocarpus siliculosus, a key role for mannitol synthesis in brown algae. Planta, 233, 261-273.

Thomas F, Barbeyron T and Michel G (2011) Evaluation of reference genes for real time quantitative PCR in the marine flavobacterium Zobellia galactanivorans. Journal of Microbiological Methods, 84, 61-66.

Dittami SM, Michel G, Collén J, Boyen C and Tonon T. (2010) Chlorophyll-binding proteins revisited--a multigenic family of light-harvesting and stress proteins from a brown algal perspective.  BMC Evolutionary Biology, 10, 365.

Czjzek M, Correc G et Michel G (2010) Sommes-nous ce que nous mangeons? L’échange de gènes du milieu marin vers la microflore intestinale chez les Japonais. Médecine Sciences, 26, 811-813.

Cast D, Cock JM, Kloareg B, Menand B, Michel G, Retaux S, Scutt C et Vialette-Guiraud A (2010) Des modèles pour comprendre l’évolution du développement des eucaryotes. Biofutur, 314, 30-33.

Bhattacharyya S, Liu H, Zhang Z, Jam M, Dudeja PK, Michel G, Linhardt RJ, and Tobacman J (2010) Carrageenan-induced innate immune response is modified by enzymes that hydrolyze distinct galactosidic bonds. Journal of Nutritional Biochemistry, 21, 906-913.

Wecker P, Klockow C, Schüler M, Dabin J, Michel G and Glöckner FO (2010) Life cycle analysis of the model organism Rhodopirellula baltica SH1T by transcriptome studies. Microbial Biotechnology, 3:583-594

Cock JM, Sterck L, Rouzé P, Scornet D, Allen AE, Amoutzias G, Anthouard V, Artiguenave F, Aury JM, Badger JH, Beszteri B, Billiau K, Bonnet E, Bothwell JH, Bowler C, Boyen C, Brownlee C, Carrano CJ, Charrier B, Cho GY, Coelho SM, Collén J, Corre E, Da Silva C, Delage L, Delaroque N, Dittami SM, Doulbeau S, Elias M, Farnham G, Gachon CM, Gschloessl B, Heesch S, Jabbari K, Jubin C, Kawai H, Kimura K, Kloareg B, Küpper FC, Lang D, Le Bail A, Leblanc C, Lerouge P, Lohr M, Lopez PJ, Martens C, Maumus F, Michel G, Miranda-Saavedra D, Morales J, Moreau H, Motomura T, Nagasato C, Napoli CA, Nelson DR, Nyvall-Collén P, Peters AF, Pommier C, Potin P, Poulain J, Quesneville H, Read B, Rensing SA, Ritter A, Rousvoal S, Samanta M, Samson G, Schroeder DC, Ségurens B, Strittmatter M, Tonon T, Tregear JW, Valentin K, von Dassow P, Yamagishi T, Van de Peer Y, Wincker P. (2010) The Ectocarpus genome and the independent evolution of multicellularity in brown algae. Nature. 2010 Jun 3;465(7298):617-21.

Hehemann J.H., Correc G., Barbeyron T., Helbert W., Czjzek M, Michel G. (2010) Transfer of carbohydrate-active enzymes from marine bacteria to Japanese gut microbiota. Nature, Apr 8;464(7290):908-12.

Hehemann J.H., Michel G., Tristan Barbeyron T. and Czjzek M. (2010). Expression, purification and preliminary X-ray diffraction analysis of the catalytic module of a ß-Agarase from the Flavobacterium Zobellia galactanivorans.   Acta Crystallogr Sect F Struct Biol Cryst Commun. Apr 1;66(Pt 4):413-7.

Groisillier A, Hervé C, Jeudy A, Rebuffet E, Chevolot Y, Pluchon PF, Flament D, Geslin C, Morgado I, Power D, Branno M, Moreau H, Michel G, Boyen C and Czjzek M . (2010). MARINE-EXPRESS: taking advantage of high throughput cloning and expression strategies for the post-genomic analysis of marine organisms. Microbial cell factories, Jun 14;9:45.

Michel G, Tonon T, Scornet D, Cock JM and Kloareg B (2010) Central and storage carbon metabolism of the brown alga Ectocarpus siliculosus. Insights into the origin and evolution of storage carbohydrates in Eukaryotes. New phytologist, 188, 67-81.

Michel G, Tonon T, Scornet D, Cock JM and Kloareg B (2010) The cell wall polysaccharide metabolism of the brown alga Ectocarpus siliculosus. Insights into the evolution of extracellular matrix polysaccharides in Eukaryotes. New phytologist, 188, 82-97

Rebuffet E., Barbeyron T., Jeudy A., Jam m., Czjzek M. and Michel G. (2010). Identification of catalytic residues and mechanistic analysis of family GH82 iota-carrageenases. Biochemistry, 7590-7599


Mark P.,Baumann M. J., Eklöf J. M., Gullfot F., Michel G., Kallas A. M., Teeri T., Brumer G. and Czjzek M. (2009) Analysis of nasturtium TmNXG1 complexes by crystallography and molecular dynamics provides detailed insight into substrate recognition by family GH16 xyloglucan endo-transglycosylases and endo-hydrolases. Proteins; 75:820–836.

Michel G., Tristan Barbeyron T., Kloareg B. and Czjzek M. (2009) The family 6 carbohydrate-binding modules have coevolved with their appendedcatalytic modules toward similar substrate specificity. Glycobiology vol. 19 no. 6 pp. 615–623, 2009

Genicot-Joncour S., Poinas A., Richard O., Potin P., Rudolph B., Kloareg B. and Helbert W. The Cyclization of the 3,6-Anhydro-Galactose Ring of i-Carrageenan Is Catalyzed by Two D-Galactose-2,6-Sulfurylases in the Red Alga Chondrus crispus1. Plant Physiology, November 2009, Vol. 151, pp. 1609–1616,

Feiters MC, Meyer-Klaucke W, Kostenko AV, Soldatov AV, Leblanc C, Michel G, Potin P, Küpper FC, Hollenstein K, Locher KP, Bevers LE,7 Hagedoorn PL and Hagen WR (2009) Anion Binding in Biological Systems. Journal of Physics: Conference Series. 190 012196.

Crawford J, Grujic O, Bruic E, Czjzek M, Grigg ME, Boulanger MJ. (2009), Structural characterization of the bradyzoite surface antigen (BSR4) from Toxoplasma gondii, a unique addition to the surface antigen glycoprotein 1-related superfamily. J Biol Chem. 284(14), 9192-8.

Ficko-Blean E, Gregg KJ, Adams JJ, Hehemann JH, Czjzek M, Smith SP, Boraston AB.(2009) Portrait of an enzyme, a complete structural analysis of a multimodular {beta}-N-acetylglucosaminidase from Clostridium perfringens. J Biol Chem. 284(15), 9876-84.