Created 28/11/2017 Updated 16/04/2020


Lund-Ricard Y., Cormier P., Morales J. and Boutet A. (2020) mTOR signaling at the crossroad between metazoan megeneration and human diseases. Int. J. Mol. Sci. 2020, 21, 2718; doi:10.3390/ijms21082718

Feizbakhsh O., Pontheaux F., Glippa V., Morales J., Ruchaud S. , Cormier P. and Roch F. (2020) A peak of H3T3 phosphorylation occurs in synchrony with mitosis in sea urchin early embryos. Cells 2020, 9, 898; doi:10.3390/cells9040898

Robert T., Johnson J.L., Guichaoua R., Yaron T.M., Bach S., Cantley L.C. and Colas P. (2020) Development of a CDK10/CycM in vitro kinase screening assay and identification of first small-molecule inhibitors. Front. Chem. 8:147.DOI: 10.3389/fchem.2020.00147

Lizarrondo, J., Dock-Bregeon, A.C., Martino, L. and Conte, M.R. (2020) Structural dynamics in the La-module of the La-related proteins, RNA biology, DOI:10.1080/15476286.2020.1733799

Hasler D., Rajyalakshmi M., Bak M., Lehmann G., Heizinger L, Wang X., Li Z.T., Sement F.M., Bruckmann A., Dock-Bregeon A.C., Merkl R., Kalb R, Grauer E., Kunstmann E., Zavolan M. Mo-Fang Liu, Fischer U., and Meister G. (2020). The Alazami Syndrome-associated protein LARP7 guides U6 small nuclear RNA modification and contributes to splicing robustness.  Molecular Cell 77, 1014–1031. DOI:10.1016/j.molcel.2020.01.001

Mokhtari Brikci-Nigassa N, Nauton L, Moreau P, Mongin O, Duval RE, Picot L, Thiéry V, Souab M, Baratte B, Ruchaud S, Bach S, Le Guevel R, Bentabed-Ababsa G, Erb W, Roisnel T, Dorcet V, Mongin F. (2020) Functionalization of 9-thioxanthone at the 1-position: From arylamino derivatives to [1]benzo(thio)pyrano[4,3,2-de]benzothieno[2,3-b]quinolines of biological interest. Bioorg Chem. 94:103347. doi: 10.1016/j.bioorg.2019.103347.

Qhobosheane MA, Legoabe LJ, Josselin B, Bach S, Ruchaud S, Petzer JP, Beteck RM. (2020) Synthesis and evaluation of 7-azaindole derivatives bearing benzocycloalkanone motifs as protein kinase inhibitors. Bioorg Med Chem.  doi: 10.1016/j.bmc.2020.115468.


Röder K, Stirnemann G, Dock-Bregeon AC, Wales DJ, Pasquali S. (2019) Structural transitions in the RNA 7SK 5' hairpin and their effect on HEXIM binding. Nucleic Acids Res. doi: 10.1093/nar/gkz1071.

Dock-Bregeon AC, Lewis KA, Conte MR. (2019) The La-related proteins: structures and interactions of a versatile superfamily of RNA-binding proteins. RNA Biology, doi: 10.1080/15476286.2019.1695712.

Papini D, Fant X, Ogawa H, Desban N, Samejima K, Feizbakhsh O, Askin B, Ly T, Earnshaw WC, Ruchaud S. (2019) Plk1-dependent cell cycle-independent furrowing triggered by phosphomimetic mutations of the INCENP STD motif. J Cell Sci. pii: jcs.234401. doi: 10.1242/jcs.234401.

Nguyen TN, Feizbakhsh O, Sfecci E, Baratte B, Delehouzé C, Garcia A, Moulin C, Colas P, Ruchaud S, Mehiri M, Bach S. (2019) Kinase-Based Screening of Marine Natural Extracts Leads to the Identification of a Cytotoxic High Molecular Weight Metabolite from the Mediterranean Sponge Crambe tailliezi. Mar Drugs. 17(10). pii: E569. doi: 10.3390/md17100569.

 Zeinyeh W, Esvan YJ, Josselin B, Baratte B, Bach S, Nauton L, Théry V, Ruchaud S, Anizon F, Giraud F, Moreau P. (2019) Kinase inhibitions in pyrido[4,3-h] and [3,4-g]quinazolines: Synthesis, SAR and molecular modeling studies. Bioorg Med Chem. 27(10):2083-2089. doi: 10.1016/j.bmc.2019.04.005.

Chassé H., Boulben S., Glippa V., Pontheaux F.,  Cormier P., Morales J. (2019) In vivo analysis of protein translation activity in sea urchin eggs and embryos. Methods in Cell Biol Vol. 151, doi: 10.1016/bs.mcb.2018.10.008

Falaise C, Cormier P, Tremblay R, Audet C, Deschênes JS, Turcotte F, François C, Seger A, Hallegraeff G, Lindquist N, Sirjacobs D, Gobert S, Lejeune P, Demoulin V, Mouget JL. (2019) Harmful or harmless: Biological effects of marennine on marine organisms. Aquat Toxicol. 209:13-25. doi: 10.1016/j.aquatox.2019.01.016.

Chassé H., Boulben S., Cormier P., Morales J. (2019) Translational control of canonical and non-canonical translation initiation factors at the sea urchin egg to embryo transition. Int J Mol Sci. 2019 Feb 1;20(3). pii: E626. doi: 10.3390/ijms20030626.

Motuhi S-E, Feizbakhsh O., Foll-Josselin B., Baratte B., Delehouzé C., Cousseau A., Fant X., Bulinski J.C., Payri C. E., Ruchaud S., Mehiri M., Bach S. (2019) Neurymenolide A, a Novel Mitotic Spindle Poison from the New Caledonian Rhodophyta Phacelocarpus neurymenioides. Mar. Drugs, 17, 93.

Tazarki H., Zeinyeh W., Esvan Y.J., Knapp S., Chatterjee D., Schröder M., Joerger A.C., Khiari J., Josselin B., Baratte B., Bach S., Ruchaud S., Anizon F., Giraud F., Moreau P. (2019). New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis. Eur. J. Med. Chem. 166  304-317.

Oukoloff K., Coquelle N., Bartolini M., Naldi M., Le Guevel R., Bach S., Josselin B., Ruchaud S., Catto M., Pisani L., Denora N., Iacobazzi R.M., Silman I., Sussman J. L., Buron F., Colletier J-P., Jean L., Routier S., Renard P-Y. (2019). Design, Biological Evaluation and X-ray Crystallography of Nanomolar Multifunctional Ligands Targeting Simultaneously Acetylcholinesterase and Glycogen Synthase Kinase-3. Eur J Med Chem. 168:58-77. doi: 10.1016/j.ejmech.2018.12.063.

Mokhtari Brikci-Nigassa N, Nauton L, Moreau P, Mongin O, Duval RE, Picot L, Thiéry V, Souab M, Baratte B, Ruchaud S, Bach S, Le Guevel R, Bentabed-Ababsa G, Erb W, Roisnel T, Dorcet V, Mongin F. (2019) Functionalization of 9-thioxanthone at the 1-position: From arylamino derivatives to [1]benzo(thio)pyrano[4,3,2-de]benzothieno[2,3-b]quinolines of biological interest. Bioorg Chem. Oct 10:103347.

Nascimento da Cruz AC, Brondani DJ, I Talo de Santana T, Oliveira da Silva L, da Oliveira Borba EF, de Faria AR, Ferreira Cavalcanti de Albuquerque J, Piessard S, Matos Ximenes R, Baratte B, Bach S, Ruchaud S, Bezerra Mendonça Junior FJ, Bazin MA, Montenegro Rabello M, Hernandes MZ, Marchand P, Gonçalves da Silva T. (2019) Biological evaluation of arylsemicarbazone derivatives as potential anticancer agents displaying kinases inhibition. Pharmaceuticals, 12, 169.

Ziane S., Mazari M.M., Safer A.M., Sad El Hachemi Amar A., Ruchaud S., Baratte B. and Bach S. (2019) Comparison between Conventional and Nonconventional Methods for the Synthesis of Some 2-Oxazolidinone Derivatives and Preliminary Investigation of Their Inhibitory Activity Against Certain Protein Kinases. Russian Journal of Organic Chemistry. Volume 55, Issue 7 (1061–1069).

Khaldoun K., Safer A., Boukabcha N., Dege N., Ruchaud R., Souab M., Bach S., Chouaih A., Saidi-Besbes S. (2019) Synthesis and evaluation of new isatin-aminorhodanine hybrids as PIM1 and CLK1 kinase inhibitors. Journal of Molecular Structure, 2019, Volume: 1192, Pages: 82-90.

Masłyk M, Janeczko M, Martyna A, Czernik S, Tokarska-Rodak M, Chwedczuk M, Foll-Josselin B, Ruchaud S, Bach S, Demchuk OM, Kubiński K. (2019) The Anti-Candida albicans Agent 4-AN Inhibits Multiple Protein Kinases. Molecules. Jan 2;24(1).

Mignerot L., Nagasato C., Peters A.F., Perrineau M-M., Scornet D., Pontheaux F., Djema W., Badis Y., Motomura T., Coelho S.M., Cock J.M. (2019) Unusual pattern of mitochondrial inheritance in the brown alga Ectocarpus. Mol Biol Evol. 36(12):2778-2789. doi: 10.1093/molbev/msz186.

Lassagne F, Duguépéroux C, Roca C, Perez C, Martinez A, Baratte B, Robert T, Ruchaud S, Bach S, Erb W, Roisnel T, Mongin F. (2019) From simple quinoxalines to potent oxazolo[5,4-f]quinoxaline inhibitors of glycogen-synthase kinase 3 (GSK3). Org Biomol Chem 18(1):154-162. doi: 10.1039/c9ob02002k.


Moundoyi H., Demouy J., Lepanse S., Morales J., Sarels B., Cormier P. (2018) Towards multiscale modeling of molecular and biochemical events occurring at fertilization time in sea urchins. In "Marine Organisms as model systems" Editors: M. Kloc and J. Kubiak, Springer (sous presse)

Chassé H., Aubert J., Boulben S., Le Corguillé G., Corre E., Cormier P., Morales J. (2018) Translatome analysis at the egg-to-embryo transition in sea urchin. Nucleic Acids Research, 46(9), 4607–4621.  doi: 10.1093/nar/gky258

Magnani, E., Macchi, F., Mancini, M., Lomazzi, V., Cogliati, S., Pistore, C., Mandruzzato, M., Dock-Bregeon, A.C. and Bonapace, I.M. (2018) UHRF1 regulates CDH1 via promoter associated non-coding RNAs in prostate cancer cells. Biochimica et biophysica acta, 1861, 258-270.

Comai G, Boutet A, Tanneberger K, Massa F, Rocha AS, Charlet A, Panzolini C, Jian Motamedi F, Brommage R, Hans W, Funck-Brentano T, Hrabe de Angelis M, Hartmann C, Cohen-Solal M, Behrens J, Schedl A. (2018) Genetic and molecular insights into genotype-phenotype relationships in osteopathia striata with cranial sclerosis (OSCS) through the analysis of novel mouse Wtx mutant alleles. J Bone Miner Res. doi: 10.1002/jbmr.3387.


Cormier P. (2017) Translation regulator ballet in meiotic spindle. Cell Cycle (Invitation News and Views) doi: 10.1080/15384101.2017.1304732.

Chassé H., Boulben S., Costache V., Cormier P., Morales J. (2017) Analysis of translation using polysome profiling. Nucleic Acids Res. 45(3):e15 doi: 10.1093/nar/gkw907

Mulner-Lorillon O., Chassé H., Morales J., Bellé R., Cormier P. (2017) MAPK/ERK activity is required for the successful progression in mitosis in sea urchin embryos. Dev. Biol. 421(2):194-203 doi: 10.1016/j.ydbio.2016.11.018.

Martinez-Zapien, D., Legrand, P., McEwen, A.G., Proux, F., Cragnolini, T., Pasquali, S. and Dock-Bregeon, A.-C. (2017) The crystal structure of the 5' functional domain of the transcription riboregulator 7SK. Nucleic Acids Res. 45(6), 3568-3579.

Boutet A. (2017) The evolution of asymmetric photosensitive structures in metazoans and the Nodal connection. Mech Dev. 147:49-60. doi: 10.1016/j.mod.2017.09.002.

Boutet A, Comai G, Charlet A, Jian Motamedi F, Dhib H, Bandiera R, Schedl A. (2017) A knock-in mouse line conditionally expressing the tumor suppressor WTX/AMER1. Genesis doi: 10.1002/dvg.23074. [Epub ahead of print]


Cormier P., Chassé H., Cosson B., Mulner-Lorillon O., Morales J. (2016) Translational control in echinoderms: the calm before the storm. In « Evolution of the Protein Synthesis Machinery and its regulation » (Springer publishers). Editors: R. Jagus and G. Hernández. pp.413-434 DOI:10.1007/978-3-319-39468-8_16.

Chassé H, Mulner-Lorillon O, Boulben S, Glippa V, Morales J, Cormier P. (2016)  Cyclin B Translation Depends on mTOR Activity after Fertilization in Sea Urchin Embryos. PLoS One. 10; 11(3): e0150318. doi: 10.1371/journal.pone.0150318.

Jiblaoui A. Barbeau J., Vivès T., Cormier P., Glippa V., Cosson B., Benvegnu T. (2016) Folate-conjugated stealth archaeosomes for the targeted delivery of novel antitumoral peptides. RSC Adv. 6, 75234-75241.

Portier, C. J., Armstrong, B. K., Baguley, B. C., Baur, X., Belyaev, I., Belle, R., .& all, Zhou, S. F. (2016) Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA). J Epidemiol Community Health, 70(8), 741-745. doi: 10.1136/jech-2015-207005.

Picard V, Mulner-Lorillon O, Bourdon J, Morales J, Cormier P, Siegel A and Belle R. (2016) Model of the delayed translation of cyclin B maternal mRNA after sea urchin fertilization. Mol Reprod Dev doi: 10.1002/mrd.22746.

Vandenplas V, Vandeghinste R, Boutet A, Mazan S, Huysseune A. Slow cycling cells in the continuous dental lamina of Scyliorhinus canicula, new evidence for stem cells in sharks (2016) Dev. Biol. 413:39-49 IF 3.1

Bourbigot, S. Dock-Bregeon, A.C., Eberling, P.,  Coutant, J.,  Kieffer, B. and Lebars I. Solution Structure of the 5’-terminal hairpin of the 7SK small nuclear RNA. (2016) RNA 22(12):1844-1858. IF 4.936


Le Grand A, Bouter A, Couturier A, Mulner-Lorillon O, Le Goff X, Chesnel F, Sire O, Le Tilly V. (2015) Investigation of the functional properties and subcellular localization of alpha human and rainbow trout estrogen receptors within a unique  yeast cellular context. J Steroid Biochem Mol Biol. 149:17-26.

Lagadec R, Laguerre L, Menuet A, Amara A, Rocancourt C, Péricard P, Godard BG, Rodicio MC, Rogriguez-Moldes I, Mayeur H, Rougemont Q, Mazan S, Boutet A. (2015) The ancestral role of Nodal signalling in breaking L/R asymmetry in the vertebrate forebrain. Nature Communications  6:6686. IF 11.4

Grande MT, Sánchez-Laorden B, López-Blau C, De Frutos CA, Boutet A, Arévalo M, Rowe RG, Weiss SJ, López-Novoa JM and Nieto MA. Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease (2015) Nature Medicine 21:989-997 IF 27.3



Laurent S., Richard A., Mulner-Lorillon O., Morales J., Flament D., Glippa V., Bourdon J., Gosselin P., Siegel A., Cormier P., Bellé R. (2014) Modelization of the regulation of protein synthesis following fertilization in sea urchin shows require- ment of two processes:  a destabilization of eIF4E:4E-BP  complex and a great stimulation of the 4E-BP-degradation  mechanism, both rapamycin-sensitive.  Frontiers in Genetics, 5:117. doi: 10.3389/fgene.2014.00117.

León K., Boulo. T., Musnier. A., Morales. J., Gauthier. C., Dupuy. L., Heyne. S., Backofen. R., Poupon. A., Cormier. P., Reiter. E. And Crepieux. P. (2014) FSH-induced signaling leads to rapamycin-sensitive phosphorylation of eIF4G at the 5’cap, and also to IRES-dependent translation. J Mol Endocrinol; 52(3):373-82. doi: 10.1530/JME-14-0009.

Masse M, Glippa V, Saad H, Le Bloas R, Gauffeny I, Berthou C, Czjzek M, Cormier P, Cosson B. (2014) An eIF4E-interacting peptide induces cell death in cancer cell lines. Cell Death and Disease, 5:e1500. doi: 10.1038/cddis.2014.457.



Gosselin P., Martineau Y., Morales J., Czjzek M., Gauffeny I., Morin E., Le Corguillé G., Pyronnet S., Cormier P., Cosson B. (2013) Tracking a redefined eIF4E-binding motif reveals Angel1 as a new partner of eIF4E. Nucleic Acids Res. 41(16):7783-7792.



Hidalgo M., Le Bouffant R., Bello V., Buisson N., Cormier P., Beaudry M., Darribère T. (2012). The translational repressor 4E-BP mediates the hypoxia-induced defects in myotome cells. J. Cell Sci 125:3989-4000

Bellé R., Marc J., Morales J., Cormier P., Mulner-Lorillon O. (2012) Letter to the editor : toxicity of roundup and glyphosate. Journal of Toxicology and Environmental Health, Part B, 15:233–237

Costache V., Bilotto S., Laguerre L., Bellé R., Cosson B., Cormier P., Morales J. (2012) Dephosphorylation of eIF2alpha is essential for protein synthesis increase and cell cycle progression after sea urchin fertilization.  Dev Biol. 365 : 303–309

Musnier A., León K., Morales J., Reiter E, Boulo T, Costache V., Vourc'h P., Heitzler D., Oulhen N., Poupon A., Boulben S., Cormier P., Crépieux P. (2012) mRNA-selective translation induced by FSH in primary Sertoli cells. Mol. Endo 26(4):669–680



Bellé, R., Pluchon P-F., Cormier P., Mulner-Lorillon O. (2011) Identification of a new isoform of eEF2 whose phosphorylation is required for completion of cell division in sea urchin embryos. Dev. Biol, 15;350(2):476-83.

Gosselin P., Oulhen N, Jam M, Ronzca J, Cormier P, Czjzek M, Cosson B (2011) The translational repressor 4E-BP called to order by eIF4E: New structural insights by SAXS. Nucleic Acids Research, 39(8):3496-503; doi: 10.1093/nar/gkq1306.