The TCCD team studies how cell cycle and development are regulated by post-transcriptional regulatory events controlling major cellular transitions. These include the conversion of an unfertilized egg into a developing embryo (egg-to-embryo transition), the transformation of a quiescent cell into a dividing cell or of an undifferentiated progenitor into a differentiated cell. We focus on two principal regulatory events: translation mechanisms and kinases signaling. Below are described the four major projects undertaken in the team.
Control of global protein synthesis during kidney regeneration of the catshark
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Function and regulation of protein kinase CDK10/CycQ
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Mitotic kinases: from fundamental biology to therapeutic opportunities
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Translation and cell cycle at the egg-to-embryo transition in sea urchin