Chargé(e) de recherche CNRS

Evolution of metabolic pathways in red and brown algae

I investigate metabolic pathway evolution, integrating information about the evolution of single enzymes with the distribution of metabolites accross lineages. This led me to develop methods to tackle directly the evolution of pathways at that level of abstraction. I am strongly interested about eukaryotic metabolic pathways for which there is a significant amount of detailed biological knowledge, such as those producing signaling molecules.



Qing X, Bernard M, Rousvoal S, Corre E, Markov GV, Peters AF, Leblanc C. 2021. Different early responses of laminariales to an endophytic infection provide insights about kelp host specificity. Frontiers in Marine Science 8:742469. doi:10.3389/fmars.2021.742469

Girard J, Lanneau G, Delage L, Leroux C, Belcour A, Got J, Collén J, Boyen C, Siegel A, Dittami S, Leblanc C, Markov GV. 2021. Semi-quantitative targeted GC-MS profiling supports a late side-chain reductase cycloartenol-to-cholesterol biosynthesis model in brown algae. Frontiers in Plant Science 12:648426. doi:10.3389/fpls.2021.648426

Belcour A, Girard J, Aite M, Delage L,Trottier C, Marteau C, Leroux C, Dittami SM, Sauleau P, Corre E, Nicolas J, Boyen C, Leblanc C, Collén J, Siegel A, Markov GV. 2020. Inferring biochemical reactions and metabolite structures to investigate metabolic pathway drift. iScience 23, 100849. doi:10.1016/j.isci.2020.100849

Nègre D, Aite M, Belcour A, Frioux C, Brillet-Guéguen L, Liu X, Bordron P, Godfroy O, Lipinska AP, Leblanc C, Siegel A, Dittami SM, Corre E, Markov GV. 2019. Genome-Scale Metabolic Networks Shed Light on the Carotenoid Biosynthesis Pathway in the Brown Algae Saccharina japonica and Cladosiphon okamuranus, Antioxidants 8, 564. doi:10.3390/antiox8110564

Teng L, Fan X, Nelson DR, Han W, Zhang X, Xu D, Renault H, Markov GV, Ye N. 2019. Diversity and evolution of cytochromes P450 in Stramenopiles, Planta 249: 647-661. hal-02065007

Aite M, Chevallier M, Frioux C, Trottier C, Got J, Paz Cortés M, Loira N, Carrier G, Dameron O, Guillaudeux N, Latorre M, Mendoza S, Markov GV, Maass A, Siegel A. 2018. Traceability, reproducibility and wiki-exploration for “à-la-carte” reconstructions of genome-scale metabolic models, Plos Comput Biol 14:e1006146. doi:10.1371/journal.pcbi.1006146. See also

Markov GV, Girard J, Laudet V, Leblanc C. 2018. Hormonally active phytochemicals from macroalgae: a largely untapped source of ligands to deorphanize nuclear receptors in emerging marine animal models. General and comparative endocrinology 265, 41-45.

Markov GV, Gutierrez-Mazariegos J, Pitrat D, Billas IML, Bonneton F, Moras D, Hasserodt J, Lecointre G, Laudet V. 2017. Origin of an Ancient Hormone / Receptor Couple Revealed by Resurrection of an Ancestral Estrogen. Science Advances 3 (3), e1601778. doi:10.1126/sciadv.1601778. Voir aussi, en français sur Planet-Vie: L'évolution des hormones stéroïdes de vertébrés élucidée par l'anatomie comparée des voies métaboliques.

Markov GV, Meyer JM, Panda O, Artyukhin AB, Claaßen M, Witte H, Schroeder FC, Sommer RJ. 2016. Functional conservation and divergence of daf-22 paralogs in P. pacificus dauer development. Molecular Biology and Evolution, 33 (10), 2506-2514. doi:10.1093/molbev/msw090

Markov GV, Baskaran P, Sommer RJ. 2015. The same or not the same: Lineage-specific gene expansions and homology relationships in multigene families in nematodes. Journal of Molecular Evolution, 80, 18-36.

Bose N, Meyer JM, Yim JJ, Mayer MG, Markov GV, Ogawa A, Schroeder FC, Sommer RJ. 2014. Natural Variation in Dauer Pheromone Production and Sensing Supports Intraspecific Competition in Nematodes. Current Biology 24, 1–6, July 7.

Markov GV, Laudet V. 2011. Origin and evolution of the ligand binding ability of nuclear receptors, Mol Cell Endocrinol, 334(1-2):21-30.

Markov GV, Tavares R, Dauphin-Villemant C, Demeneix BA, Baker ME, Laudet V. 2009. Independent elaboration of steroid hormone signaling pathways in metazoans. Proc Natl Acad Sci U S A. 106:11913-8.

Markov G, Lecointre G, Demeneix B, Laudet V. The "street light syndrome", or how protein taxonomy can bias experimental manipulations. Bioessays. 2008 Apr;30(4):349-57.