Created 28/11/2017 Updated 02/09/2019


Zeinyeh W, Esvan YJ, Josselin B, Baratte B, Bach S, Nauton L, Théry V, Ruchaud S, Anizon F, Giraud F, Moreau P. Kinase inhibitions in pyrido[4,3-h] and [3,4-g]quinazolines: Synthesis, SAR and molecular modeling studies. Bioorg Med Chem. 2019 May 15;27(10):2083-2089. doi: 10.1016/j.bmc.2019.04.005.

Chassé H., Boulben S., Glippa V., Pontheaux F.,  Cormier P., Morales J. (2019) In vivo analysis of protein translation activity in sea urchin eggs and embryos. Methods in Cell Biol Vol. 151, doi: 10.1016/bs.mcb.2018.10.008

Falaise C, Cormier P, Tremblay R, Audet C, Deschênes JS, Turcotte F, François C, Seger A, Hallegraeff G, Lindquist N, Sirjacobs D, Gobert S, Lejeune P, Demoulin V, Mouget JL. (2019) Harmful or harmless: Biological effects of marennine on marine organisms. Aquat Toxicol. 209:13-25. doi: 10.1016/j.aquatox.2019.01.016.

Chassé H., Boulben S., Cormier P., Morales J. (2019) Translational control of canonical and non-canonical translation initiation factors at the sea urchin egg to embryo transition. Int J Mol Sci. 2019 Feb 1;20(3). pii: E626. doi: 10.3390/ijms20030626.

Motuhi S-E, Feizbakhsh O., Foll-Josselin B., Baratte B., Delehouzé C., Cousseau A., Fant X., Bulinski J.C., Payri C. E., Ruchaud S., Mehiri M., Bach S. (2019) Neurymenolide A, a Novel Mitotic Spindle Poison from the New Caledonian Rhodophyta Phacelocarpus neurymenioides. Mar. Drugs, 17, 93.

Tazarki H., Zeinyeh W., Esvan Y.J., Knapp S., Chatterjee D., Schröder M., Joerger A.C., Khiari J., Josselin B., Baratte B., Bach S., Ruchaud S., Anizon F., Giraud F., Moreau P. (2019). New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis. Eur. J. Med. Chem. 166  304-317.

Oukoloff K., Coquelle N., Bartolini M., Naldi M., Le Guevel R., Bach S., Josselin B., Ruchaud S., Catto M., Pisani L., Denora N., Iacobazzi R.M., Silman I., Sussman J. L., Buron F., Colletier J-P., Jean L., Routier S., Renard P-Y. (2019). Design, Biological Evaluation and X-ray Crystallography of Nanomolar Multifunctional Ligands Targeting Simultaneously Acetylcholinesterase and Glycogen Synthase Kinase-3. Journal of Medicinal Chemistry. In press.


Moundoyi H., Demouy J., Lepanse S., Morales J., Sarels B., Cormier P. (2018) Towards multiscale modeling of molecular and biochemical events occurring at fertilization time in sea urchins. In "Marine Organisms as model systems" Editors: M. Kloc and J. Kubiak, Springer (sous presse)

Chassé H., Aubert J., Boulben S., Le Corguillé G., Corre E., Cormier P., Morales J. (2018) Translatome analysis at the egg-to-embryo transition in sea urchin. Nucleic Acids Research, 46(9), 4607–4621.  doi: 10.1093/nar/gky258

Magnani, E., Macchi, F., Mancini, M., Lomazzi, V., Cogliati, S., Pistore, C., Mandruzzato, M., Dock-Bregeon, A.C. and Bonapace, I.M. (2018) UHRF1 regulates CDH1 via promoter associated non-coding RNAs in prostate cancer cells. Biochimica et biophysica acta, 1861, 258-270.

Comai G, Boutet A, Tanneberger K, Massa F, Rocha AS, Charlet A, Panzolini C, Jian Motamedi F, Brommage R, Hans W, Funck-Brentano T, Hrabe de Angelis M, Hartmann C, Cohen-Solal M, Behrens J, Schedl A. (2018) Genetic and molecular insights into genotype-phenotype relationships in osteopathia striata with cranial sclerosis (OSCS) through the analysis of novel mouse Wtx mutant alleles. J Bone Miner Res. doi: 10.1002/jbmr.3387.


Cormier P. (2017) Translation regulator ballet in meiotic spindle. Cell Cycle (Invitation News and Views) doi: 10.1080/15384101.2017.1304732.

Chassé H., Boulben S., Costache V., Cormier P., Morales J. (2017) Analysis of translation using polysome profiling. Nucleic Acids Res. 45(3):e15 doi: 10.1093/nar/gkw907

Mulner-Lorillon O., Chassé H., Morales J., Bellé R., Cormier P. (2017) MAPK/ERK activity is required for the successful progression in mitosis in sea urchin embryos. Dev. Biol. 421(2):194-203 doi: 10.1016/j.ydbio.2016.11.018.

Martinez-Zapien, D., Legrand, P., McEwen, A.G., Proux, F., Cragnolini, T., Pasquali, S. and Dock-Bregeon, A.-C. (2017) The crystal structure of the 5' functional domain of the transcription riboregulator 7SK. Nucleic Acids Res. 45(6), 3568-3579.

Boutet A. (2017) The evolution of asymmetric photosensitive structures in metazoans and the Nodal connection. Mech Dev. 147:49-60. doi: 10.1016/j.mod.2017.09.002.

Boutet A, Comai G, Charlet A, Jian Motamedi F, Dhib H, Bandiera R, Schedl A. (2017) A knock-in mouse line conditionally expressing the tumor suppressor WTX/AMER1. Genesis doi: 10.1002/dvg.23074. [Epub ahead of print]


Cormier P., Chassé H., Cosson B., Mulner-Lorillon O., Morales J. (2016) Translational control in echinoderms: the calm before the storm. In « Evolution of the Protein Synthesis Machinery and its regulation » (Springer publishers). Editors: R. Jagus and G. Hernández. pp.413-434 DOI:10.1007/978-3-319-39468-8_16.

Chassé H, Mulner-Lorillon O, Boulben S, Glippa V, Morales J, Cormier P. (2016)  Cyclin B Translation Depends on mTOR Activity after Fertilization in Sea Urchin Embryos. PLoS One. 10; 11(3): e0150318. doi: 10.1371/journal.pone.0150318.

Jiblaoui A. Barbeau J., Vivès T., Cormier P., Glippa V., Cosson B., Benvegnu T. (2016) Folate-conjugated stealth archaeosomes for the targeted delivery of novel antitumoral peptides. RSC Adv. 6, 75234-75241.

Portier, C. J., Armstrong, B. K., Baguley, B. C., Baur, X., Belyaev, I., Belle, R., .& all, Zhou, S. F. (2016) Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA). J Epidemiol Community Health, 70(8), 741-745. doi: 10.1136/jech-2015-207005.

Picard V, Mulner-Lorillon O, Bourdon J, Morales J, Cormier P, Siegel A and Belle R. (2016) Model of the delayed translation of cyclin B maternal mRNA after sea urchin fertilization. Mol Reprod Dev doi: 10.1002/mrd.22746.

Vandenplas V, Vandeghinste R, Boutet A, Mazan S, Huysseune A. Slow cycling cells in the continuous dental lamina of Scyliorhinus canicula, new evidence for stem cells in sharks (2016) Dev. Biol. 413:39-49 IF 3.1

Bourbigot, S. Dock-Bregeon, A.C., Eberling, P.,  Coutant, J.,  Kieffer, B. and Lebars I. Solution Structure of the 5’-terminal hairpin of the 7SK small nuclear RNA. (2016) RNA 22(12):1844-1858. IF 4.936


Le Grand A, Bouter A, Couturier A, Mulner-Lorillon O, Le Goff X, Chesnel F, Sire O, Le Tilly V. (2015) Investigation of the functional properties and subcellular localization of alpha human and rainbow trout estrogen receptors within a unique  yeast cellular context. J Steroid Biochem Mol Biol. 149:17-26.

Lagadec R, Laguerre L, Menuet A, Amara A, Rocancourt C, Péricard P, Godard BG, Rodicio MC, Rogriguez-Moldes I, Mayeur H, Rougemont Q, Mazan S, Boutet A. (2015) The ancestral role of Nodal signalling in breaking L/R asymmetry in the vertebrate forebrain. Nature Communications  6:6686. IF 11.4

Grande MT, Sánchez-Laorden B, López-Blau C, De Frutos CA, Boutet A, Arévalo M, Rowe RG, Weiss SJ, López-Novoa JM and Nieto MA. Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease (2015) Nature Medicine 21:989-997 IF 27.3



Laurent S., Richard A., Mulner-Lorillon O., Morales J., Flament D., Glippa V., Bourdon J., Gosselin P., Siegel A., Cormier P., Bellé R. (2014) Modelization of the regulation of protein synthesis following fertilization in sea urchin shows require- ment of two processes:  a destabilization of eIF4E:4E-BP  complex and a great stimulation of the 4E-BP-degradation  mechanism, both rapamycin-sensitive.  Frontiers in Genetics, 5:117. doi: 10.3389/fgene.2014.00117.

León K., Boulo. T., Musnier. A., Morales. J., Gauthier. C., Dupuy. L., Heyne. S., Backofen. R., Poupon. A., Cormier. P., Reiter. E. And Crepieux. P. (2014) FSH-induced signaling leads to rapamycin-sensitive phosphorylation of eIF4G at the 5’cap, and also to IRES-dependent translation. J Mol Endocrinol; 52(3):373-82. doi: 10.1530/JME-14-0009.

Masse M, Glippa V, Saad H, Le Bloas R, Gauffeny I, Berthou C, Czjzek M, Cormier P, Cosson B. (2014) An eIF4E-interacting peptide induces cell death in cancer cell lines. Cell Death and Disease, 5:e1500. doi: 10.1038/cddis.2014.457.



Gosselin P., Martineau Y., Morales J., Czjzek M., Gauffeny I., Morin E., Le Corguillé G., Pyronnet S., Cormier P., Cosson B. (2013) Tracking a redefined eIF4E-binding motif reveals Angel1 as a new partner of eIF4E. Nucleic Acids Res. 41(16):7783-7792.



Hidalgo M., Le Bouffant R., Bello V., Buisson N., Cormier P., Beaudry M., Darribère T. (2012). The translational repressor 4E-BP mediates the hypoxia-induced defects in myotome cells. J. Cell Sci 125:3989-4000

Bellé R., Marc J., Morales J., Cormier P., Mulner-Lorillon O. (2012) Letter to the editor : toxicity of roundup and glyphosate. Journal of Toxicology and Environmental Health, Part B, 15:233–237

Costache V., Bilotto S., Laguerre L., Bellé R., Cosson B., Cormier P., Morales J. (2012) Dephosphorylation of eIF2alpha is essential for protein synthesis increase and cell cycle progression after sea urchin fertilization.  Dev Biol. 365 : 303–309

Musnier A., León K., Morales J., Reiter E, Boulo T, Costache V., Vourc'h P., Heitzler D., Oulhen N., Poupon A., Boulben S., Cormier P., Crépieux P. (2012) mRNA-selective translation induced by FSH in primary Sertoli cells. Mol. Endo 26(4):669–680



Bellé, R., Pluchon P-F., Cormier P., Mulner-Lorillon O. (2011) Identification of a new isoform of eEF2 whose phosphorylation is required for completion of cell division in sea urchin embryos. Dev. Biol, 15;350(2):476-83.

Gosselin P., Oulhen N, Jam M, Ronzca J, Cormier P, Czjzek M, Cosson B (2011) The translational repressor 4E-BP called to order by eIF4E: New structural insights by SAXS. Nucleic Acids Research, 39(8):3496-503; doi: 10.1093/nar/gkq1306.