Created 10/12/2015 Updated 06/10/2023

List of publications by PCF team


Hatem, A., Esperti, S., Murciano, N., Qiao, M., Giustina Rotordam, M., Becker, N., Nader, E., Maurer, F., Pérès, L., Bouyer, G., Kaestner, L., Connes, P., Egée, S., 2023. Adverse effects of delta-9-tetrahydrocannabinol on sickle red blood cells. Am. J. Hematol. n/a.


van Dijk, M.J., van Oirschot, B.A., Harrison, A.N., Recktenwald, S.M., Qiao, M., Stommen, A., Cloos, A.-S., Vanderroost, J., Terrasi, R., Dey, K., Bos, J., Rab, M.A.E., Bogdanova, A., Minetti, G., Muccioli, G.G., Tyteca, D., Egée, S., Kaestner, L., Molday, R.S., van Beers, E.J., van Wijk, R., 2023. A novel missense variant in ATP11C is associated with reduced red blood cell phosphatidylserine flippase activity and mild hereditary hemolytic anemia. Am. J. Hematol. n/a.


Hatem, A., Poussereau, G., Gachenot, M., Pérès, L., Bouyer, G., Egée, S., 2023. Dual action of Dooku1 on PIEZO1 channel in human red blood cells. Front. Physiol. 14.


Nader, E., Conran, N., Leonardo, F.C., Hatem, A., Boisson, C., Carin, R., Renoux, C., Costa, F.F., Joly, P., Brito, P.L., Esperti, S., Bernard, J., Gauthier, A., Poutrel, S., Bertrand, Y., Garcia, C., Saad, S.T.O., Egée, S., Connes, P., 2023. Piezo1 activation augments sickling propensity and the adhesive properties of sickle red blood cells in a calcium-dependent manner. Br. J. Haematol. 00, 1–12.




Dalimot, J.J., Klei, T.R.L., Beuger, B.M., Dikmen, Z., Bouwman, S.A.M., Mombo-Ngoma, G., Zoleko-Manego, R., Ndzebe-Ndoumba, W.F., Egée, S., Kuijpers, T.W., Grobusch, M.P., van Bruggen, R., 2022. Malaria-associated adhesion molecule activation facilitates the destruction of uninfected red blood cells. Blood Advances.


von Lindern, M., Egée, S., Bianchi, P., Kaestner, L., 2022. The Function of Ion Channels and Membrane Potential in Red Blood Cells: Toward a Systematic Analysis of the Erythroid Channelome. Frontiers in Physiology. 13.


Buks, R., Dagher, T., Rotordam, M.G., Monedero Alonso, D., Cochet, S., Gautier, E.-F., Chafey, P., Cassinat, B., Kiladjian, J.-J., Becker, N., Plo, I., Egée, S., El Nemer, W., 2022. Altered Ca2+ Homeostasis in Red Blood Cells of Polycythemia Vera Patients Following Disturbed Organelle Sorting during Terminal Erythropoiesis. Cells 11, 49.




Monedero Alonso, D., Pérès, L., Hatem, A., Bouyer, G., Egée, S., 2021. The Chloride Conductance Inhibitor NS3623 Enhances the Activity of a Non-selective Cation Channel in Hyperpolarizing Conditions. Frontiers in Physiology 12, 1705.


Egée, S., Kaestner, L., 2021. The Transient Receptor Potential Vanilloid Type 2 (TRPV2) Channel–A New Druggable Ca2+ Pathway in Red Cells, Implications for Red Cell Ion Homeostasis. Frontiers in Physiology 12, 850.


Mansour-Hendili, L., Egée, S., Monedero-Alonso, D., Bouyer, G., Godeau, B., Badaoui, B., Lunati, A., Noizat, C., Aissat, A., Kiger, L., Mekki, C., Picard, V., Moutereau, S., Fanen, P., Bartolucci, P., Garçon, L., Galactéros, F., Funalot, B., 2021. Multiple thrombosis in a patient with Gardos channelopathy and a new KCNN4 mutation. American Journal of Hematology 96, E318–E321.


Pérès, L., Alonso, D.M., Nudel, M., Figeac, M., Bruge, J., Sebda, S., Picard, V., Nemer, W.E., Preudhomme, C., Rose, C., Egée, S., Bouyer, G., 2021. Characterisation of Asp669Tyr Piezo1 cation channel activity in red blood cells: an unexpected phenotype. British Journal of Haematology 194, e51–e55.


Filser, M., Giansily-Blaizot, M., Grenier, M., Monedero Alonso, D., Bouyer, G., Pérès, L., Egée, S., Aral, B., Airaud, F., Da Costa, L., Picard, V., Cougoul, P., Palach, M., Béziau, S., Garrec, C., Aguilar-Martinez, P., Gardie, B., Girodon, F., 2021. Increased incidence of germline PIEZO1 mutations in individuals with idiopathic erythrocytosis. Blood 137, 1828–1832.




Bouyer, G., Barbieri, D., Dupuy, F., Marteau, A., Sissoko, A., N’Dri, M.-E., Neveu, G., Bedault, L., Khodabux, N., Roman, D., Houzé, S., Siciliano, G., Alano, P., Martins, R.M., Lopez-Rubio, J.-J., Clain, J., Duval, R., Egée, S., Lavazec, C. (2020). Plasmodium falciparum sexual parasites regulate infected erythrocyte permeability. Communications Biology. 3, 1–10.


Fermo, E., Monedero-Alonso, D., Petkova-Kirova, P., Makhro, A., Pérès, L., Bouyer, G., Marcello, A.P., Longo, F., Graziadei, G., Barcellini, W., Bogdanova, A., Egee, S., Kaestner, L., Bianchi, P., 2020. Gardos channelopathy: functional analysis of a novel KCNN4 variant. Blood Advances 4, 6336–6341.


Kaestner, L., Bogdanova, A., and Egee, S. (2020) Calcium Channels and Calcium-Regulated Channels in Human Red Blood Cells, In Calcium Signaling (Islam, M. S., Ed.), pp 625-648, Springer International Publishing, Cham.


Nader, E., Monedero, D., Robert, M., Skinner, S., Stauffer, E., Cibiel, A., Germain, M., Hugonnet, J., Scheer, A., Joly, P., Renoux, C., Connes, P., and Égée, S. (2020) Impact of a 10 km running trial on eryptosis, red blood cell rheology, and electrophysiology in endurance trained athletes: a pilot study, European Journal of Applied Physiology 120, 255-266.




Rotordam, M. G., Fermo, E., Becker, N., Barcellini, W., Brüggemann, A., Fertig, N., Egée, S., Rapedius, M., Bianchi, P., and Kaestner, L. (2019) A novel gain-of-function mutation of Piezo1 is functionally affirmed in red blood cells by high-throughput patch clamp, Haematologica 104, e179-e183.




Kaestner, L., and Egee, S. (2018) Commentary: Voltage Gating of Mechanosensitive PIEZO Channels, Frontiers in Physiology 9, 1565.


Marginedas-Freixa, I., Alvarez, C., Moras, M., Hattab, C., Bouyer, G., Chene, A., Lefevre, S., Le Van Kim, C., Bihel, F., Schwarzbaum, P., and Ostuni, M. (2018) Induction of ATP Release, PPIX Transport, and Cholesterol Uptake by Human Red Blood Cells Using a New Family of TSPO Ligands, International Journal of Molecular Sciences 19, 3098.




Hertz, L., Huisjes, R., Llaudet-Planas, E., Petkova-Kirova, P., Makhro, A., Danielczok, J. G., Egee, S., Del Mar Manu-Pereira, M., van Wijk, R., Vives Corrons, J. L., Bogdanova, A., and Kaestner, L. (2017) Is Increased Intracellular Calcium in Red Blood Cells a Common Component in the Molecular Mechanism Causing Anemia?, Frontiers in Physiology 8, 673.




Marginedas-Freixa, I., Hattab, C., Bouyer, G., Halle, F., Chene, A., Lefevre, S. D., Cambot, M., Cueff, A., Schmitt, M., Gamain, B., Lacapere, J. J., Egee, S., Bihel, F., Le Van Kim, C., and Ostuni, M. A. (2016) TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood, Scientific Reports 6, 33516.


Bouyer, G., Reininger, L., Ramdani, G., D. Phillips, L., Sharma, V., Egee, S., Langsley, G., and Lasonder, E. (2016) Plasmodium falciparum infection induces dynamic changes in the erythrocyte phospho-proteome, Blood Cells, Molecules, and Diseases 58, 35-44.


Slavic, K., Krishna, S., Lahree, A., Bouyer, G., Hanson, K. K., Vera, I., Pittman, J. K., Staines, H. M., and Mota, M. M. (2016) A vacuolar iron-transporter homologue acts as a detoxifier in Plasmodium, Nature Communications 7, 10403.




Pulcini, S., Staines, H. M., Lee, A. H., Shafik, S. H., Bouyer, G., Moore, C. M., Daley, D. A., Hoke, M. J., Altenhofen, L. M., Painter, H. J., Mu, J., Ferguson, D. J., Llinas, M., Martin, R. E., Fidock, D. A., Cooper,

R. A., and Krishna, S. (2015) Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities, Scientific reports 5, 14552.


Egee S., Bouyer G., Thomas S. (2015) Permeabilization of host cell membrane .Encyclopedia of Malaria Article ID : 372342 · ChapterID : 38 Springer Reference,




Ollivaux, C., Soyez, D., and Toullec, J. Y. (2014) Biogenesis of D-amino acid containing peptides/proteins: where, when and how?, Journal of peptide science : an official publication of the European Peptide Society 20, 595-612.




Toullec, J. Y., Corre, E., Bernay, B., Thorne, M. A., Cascella, K., Ollivaux, C., Henry, J., and Clark, M. S. (2013) Transcriptome and peptidome characterisation of the main neuropeptides and peptidic hormones of a euphausiid: the Ice Krill, Euphausia crystallorophias, PloS one 8, e71609.


Moersdorf, D., Egee, S., Hahn, C., Hanf, B., Ellory, C., Thomas, S., and Bernhardt, I. (2013) Transmembrane Potential of Red Blood Cells Under Low Ionic Strength Conditions, Cellular Physiology and Biochemistry 31, 875-882.


Minetti, G., Egee, S., Moersdorf, D., Steffen, P., Makhro, A., Achilli, C., Ciana, A., Wang, J., Bouyer, G., Bernhardt, I., Wagner, C., Thomas, S., Bogdanova, A., and Kaestner, L. (2013) Red cell investigations: Art and artefacts, Blood Reviews 27, 91-101.




Sanyal, S., Egee, S., Bouyer, G., Perrot, S., Safeukui, I., Bischoff, E., Buffet, P., Deitsch, K. W., Mercereau-Puijalon, O., David, P. H., Templeton, T. J., and Lavazec, C. (2012) Plasmodium falciparum STEVOR proteins impact erythrocyte mechanical properties, Blood 119, E1-E8.


Toure, A., Langsley, G., and Egee, S. (2012) Spermatozoa and Plasmodium zoites: the same way to invade oocyte and host cells?, Microbes and Infection 14, 874-879.


Bouyer, G., Thomas, S., and Egée, S. (2012) Patch-Clamp Analysis of Membrane Transport in Erythrocytes, Patch Clamp Technique, Fatima Shad Kaneez (Ed.), ISBN: 978-953-51-0406-3, InTech, Available from:




Bouyer, G., Cueff, A., Egee, S., Kmiecik, J., Maksimova, Y., Glogowska, E., Gallagher, P. G., and Thomas, S. L. Y. (2011) Erythrocyte peripheral type benzodiazepine receptor/voltage-dependent anion channels are upregulated by Plasmodium falciparum, Blood 118, 2305-2312


Soyez, D., Toullec, J. Y., Montagne, N., and Ollivaux, C. (2011) Experimental strategies for the analysis of D-amino acid containing peptides in crustaceans: a review, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 879, 3102-3107


Thomas, S. L. Y., Bouyer, G., Cueff, A., Egee, S., Glogowska, E., and Ollivaux, C. (2011) Ion channels in human red blood cell membrane: Actors or relics?, Blood Cells Molecules and Diseases 46, 261-265.


Bouyer G, Thomas SLY, Egee S (2011) Protein Kinase-Regulated Inwardly Rectifying Anion and Organic Osmolyte Channels in Malaria-Infected Erythrocytes. Open Biology Journal 4: 10-17.




Cueff, A., Seear, R., Dyrda, A., Bouyer, G., Egee, S., Esposito, A., Skepper, J., Tiffert, T., Lew, V. L., and Thomas, S. L. Y. (2010) Effects of elevated intracellular calcium on the osmotic fragility of human red blood cells, Cell Calcium 47, 29-36.


Dyrda, A., Cytlak, U., Ciuraszkiewicz, A., Lipinska, A., Cueff, A., Bouyer, G., Egee, S., Bennekou, P., Lew, V. L., and Thomas, S. L. Y. (2010) Local Membrane Deformations Activate Ca2+-Dependent K+ and Anionic Currents in Intact Human Red Blood Cells, PLoS ONE 5.


Glogowska, E., Dyrda, A., Cueff, A., Bouyer, G., Egee, S., Bennekou, P., and Thomas, S. L. Y. (2010) Anion conductance of the human red cell is carried by a maxi-anion channel, Blood Cells Molecules and Diseases 44, 243-251.




Cueff, A., Dyrda, A., Bouyer, G., Egee, S., Sees, R., Esposito, A., Skepper, J., Tiffert, T., Lew, V. L., and Thomas, S. (2009) Analysis of the relation between water content and osmotic fragility of human red blood cells, Clinical Biochemistry 42, 1851-1851.


Dyrda, A., Cytlak, U., Ciuraszkiewicz, A., Cueff, A., Lipinska, A., Bouyer, G., Egee, S., Bennekou, P., and Thomas, S. (2009) Gardos and anionic channels activation induced by local membrane deformation in intact human red blood cells, Clinical Biochemistry 42, 1858-1858.


Egee, S., Bouyer, G., Merckx, A., Langsley, G., and Thomas, S. (2009) Implication of Plasmodium falciparum protein-kinase a in channel activation upon malaria infection, Clinical Biochemistry 42, 1860-1860.


Merckx, A., Bouyer, G., Thomas, S. L. Y., Langsley, G., and Egee, S. (2009) Anion channels in Plasmodium-falciparum-infected erythrocytes and protein kinase A, Trends in Parasitology 25, 139-144.




Lapaix, F., Bouyer, G., Thomas, S., and Egee, S. (2008) Further characterization of cation channels present in the chicken red blood cell membrane, Bioelectrochemistry 73, 129-136.


Merckx, A., Nivez, M.-P., Bouyer, G., Alano, P., Langsley, G., Deitsch, K., Thomas, S., Doerig, C., and Egee, S. (2008) Plasmodium falciparum regulatory subunit of cAMP-dependent PKA and anion channel conductance, PLoS Pathogens 4.




Bouyer, G., Egee, S., and Thomas, S. L. Y. (2007) Toward a unifying model of malaria-induced channel activity, Proceedings of the National Academy of Sciences of the United States of America 104, 11044-11049.


Decherf, G., Bouyer, G., Egee, S., and Thomas, S. L. Y. (2007) Chloride channels in normal and cystic fibrosis human erythrocyte membrane, Blood Cells Molecules and Diseases 39, 24-34.


Staines, H. M., Alkhalil, A., Allen, R. J., De Jonge, H. R., Derbyshire, E., Egee, S., Ginsburg, H., Hill, D. A., Huber, S. M., Kirk, K., Lang, F., Lisk, G., Oteng, E., Pillai, A. D., Rayavara, K., Rouhani, S., Saliba, K. J., Shen, C., Solomon, T., Thomas, S. L. Y., Verloo, P., and Desai, S. A. (2007) Electrophysiological studies of malaria parasite-infected erythrocytes: Current status, International Journal for Parasitology 37, 475-482.




Bouyer, G., Egee, S., and Thomas, S. L. (2006) Three types of spontaneously active anionic channels in malaria-infected human red blood cells, Blood Cells Molecules and Diseases 36, 248-254.




Thomas, S. L., and Egee, S. (2005) New permeation pathways, Molecular Approaches to Malaria, 384-396.


S. L. Thomas, and S. Egee, New permeation pathways, in Molecular Approaches to Malaria,  Sherman, I. W., (Ed.), ASM Press, Washington D.C., 2005, pp. 384-396




Decherf, G., Egee, S., Staines, H. M., Ellory, J. C., and Thomas, S. L. (2004) Anionic channels in malaria-infected human red blood cells, Blood Cells Molecules and Diseases 32, 366-371.


Labaied, M., Dagan, A., Dellinger, M., Geze, M., Egee, S., Thomas, S. L., Wang, C. B., Gatt, S., and Grellier, P. (2004) Anti-Plasmodium activity of ceramide analogs, Malaria Journal 3.




Staines, H. M., Powell, T., Ellory, J. C., Egee, S., Lapaix, F., Decherf, G., Thomas, S. L. Y., Duranton, C., Lang, F., and Huber, S. M. (2003) Modulation of whole-cell currents in Plasmodium falciparum-infected human red blood cells by holding potential and serum, Journal of Physiology-London 552, 177-183.




Drew, C., Lapaix, F., Egee, S., Thomas, S., Ellory, J. C., and Staines, H. M. (2002) Age-dependent decreases in cation transport in chicken erythrocytes, Journal of Physiology-London 539, 20P-21P.


Drew, C., Lapaix, F., Egee, S., Thomas, S., Ellory, J. C., and Staines, H. M. (2002) Age-dependent changes in cation transport in the chicken erythrocyte, Comparative Biochemistry and Physiology a-Molecular and Integrative Physiology 133, 169-178.


Egee, S., Lapaix, F., Decherf, G., Staines, H. M., Ellory, J. C., Doerig, C., and Thomas, S. L. Y. (2002) A stretch-activated anion channel is up-regulated by the malaria parasite Plasmodium falciparum, Journal of Physiology-London 542, 795-801.


Lapaix, F., Egee, S., Gibert, L., Decherf, G., and Thomas, S. L. Y. (2002) ATP-sensitive K+ and Ca2+-activated K+ channels in lamprey (Petromyzon marinus) red blood cell membrane, Pflugers Archiv-European Journal of Physiology 445, 152-160.


Staines, H. M., Godfrey, E. M., Lapaix, F., Egee, S., Thomas, S., and Ellory, J. C. (2002) Osmolyte channels in malaria-infected red cells, Journal of Physiology-London 539, 14P-15P.


Staines, H. M., Godfrey, E. M., Lapaix, F., Egee, S., Thomas, S., and Ellory, J. C. (2002) Two functionally distinct organic osmolyte pathways in Plasmodium gallinaceum-infected chicken red blood cells, Biochimica Et Biophysica Acta-Biomembranes 1561, 98-108




Thomas, S. L. Y., Egee, S., Lapaix, F., Kaestner, L., Staines, H. M., and Ellory, J. C. (2001) Malaria parasite Plasmodium gallinaceum up-regulates host red blood cell channels, Febs Letters 500, 45-51.




Egee, S., Lapaix, F., Cossins, A. R., and Thomas, S. L. Y. (2000) The role of anion and cation channels in volume regulatory responses in trout red blood cells, Bioelectrochemistry 52, 133-149.


Mignen, O., Egee, P., Liberge, M., and Harvey, B. J. (2000) Basolateral outward rectifier chloride channel in isolated crypts of mouse colon, American Journal of Physiology-Gastrointestinal and Liver Physiology 279, G277-G287.


Thomas, S., and Egee, S. (2000) ATP-sensitive K+ and calcium-activated K+ channels in lamprey red blood cell membrane, Journal of Physiology-London 523, 17P-18P.


Thomas, S., Lapaix, F., and Egee, S. (2000) Role of anion and cation channels in volume regulatory response in lamprey erythrocytes, Journal of Physiology-London 526, 19P-20P


Nonnotte, G. and Egee, S. (2000) Régulation de l'équilibre acido-basique et du volume cellulaire lors de changements de salinité chez les espèces euryhalines., in Le Milieu Aquatique : Interactions des facteurs environnementaux et impacts sur les organismes vivants, Nonnotte, G., Sébert, P., and Devauchelle, N., (Eds.), Anaximandre, Lesneven, 2000, pp. 58-73




Egee, S., Cabioch, S., and Thomas, S. (1998) Are ion channels involved in volume regulation in trout red blood cells following osmotic shock?, Journal of Physiology-London 511P, 150P-150P.


Egee, S., Mignen, O., Harvey, B. J., and Thomas, S. (1998) Chloride and non-selective cation channels in unstimulated trout red blood cells, Journal of Physiology-London 511, 213-224.


Thomas, S., and Egee, S. (1998) Fish red blood cells: Characteristics and physiological role of the membrane ion transporters, Comparative Biochemistry and Physiology a-Molecular and Integrative Physiology 119, 79-86.




Egee, S., Harvey, B. J., and Thomas, S. (1997) Volume-activated DIDS-sensitive whole-cell chloride currents in trout red blood cells, Journal of Physiology-London 504, 57-63.


Mignen, O., Egee, S., Pennec, J. P., Harvey, B. J., and Thomas, S. (1997) Outward rectifier chloride channels in the baso-lateral membrane of crypts isolated from mouse distal colon, Journal of Physiology-London 499P, P30-P31.




Egee, S., Harvey, B. J., and Thomas, S. (1996) Determination of chlorine conductance in volume regulation of nucleated fish erythrocytes, Archives of Physiology and Biochemistry 104, D100-D100