Thematics
Cell differentiation and Cell death
- Ion channel and membrane transport
- Kinase and necroptosis
- Cell physiology in health & diseases
People
Stéphane BACH
Responsable scientifique de la plateforme de criblage KISSf.
Ingénieur de recherche CNRS
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Publications
Pharmacophore-guided optimization of the hit compound CTN1122 in the design of promising imidazo[1,2- a ]pyrazine derivatives targeting the casein kinase 1 for antileishmanial therapy
Lhana Tisseur, Cédric Logé, Sandrine Cojean, Khadidiatou Gassama, Lilian Karcher, et al.. Pharmacophore-guided optimization of the hit compound CTN1122 in the design of promising imidazo[1,2- a ]pyrazine derivatives targeting the casein kinase 1 for antileishmanial therapy. RSC Medicinal Chemistry, 2025, 16, pp.3746-3763. ⟨10.1039/d5md00257e⟩. ⟨hal-05173262⟩
Structured Model Conserving Biomass for the Size-spectrum Evolution in Aquatic Ecosystems
Laura Kanzler, Benoît Perthame, Benoît Sarels. Structured Model Conserving Biomass for the Size-spectrum Evolution in Aquatic Ecosystems. Journal of Mathematical Biology, 2024, 88 (3), pp.26. ⟨10.1007/s00285-023-02043-y⟩. ⟨hal-03895919v2⟩
Target fishing reveals PfPYK-1 and PfRab6 as potential targets of an antiplasmodial 4-anilino-2-trichloromethylquinazoline hit compound
C. Kieffer, N. Primas, S. Hutter, A. Merckx, L. Reininger, et al.. Target fishing reveals PfPYK-1 and PfRab6 as potential targets of an antiplasmodial 4-anilino-2-trichloromethylquinazoline hit compound. Bioorganic and Medicinal Chemistry, 2024, 102, pp.117654. ⟨10.1016/j.bmc.2024.117654⟩. ⟨hal-04503278⟩
Characterization of cationic conductance in Red Blood Cells; insights from pharmacological and pathophysiological studies
Aline Hatem. Characterization of cationic conductance in Red Blood Cells; insights from pharmacological and pathophysiological studies. Cellular Biology. Sorbonne Université, 2024. English. ⟨NNT : 2024SORUS008⟩. ⟨tel-04563223⟩
Modifying positions 2 or 8 of the imidazo[1,2-a]pyrazine lead compound CTN1122 affects its antileishmanial activity, L-CK1.2 kinase inhibition, and safety profile
Lhana Tisseur, Marc-Antoine Bazin, Sandrine Cojean, Fabrice Pagniez, Cédric Logé, et al.. Modifying positions 2 or 8 of the imidazo[1,2-a]pyrazine lead compound CTN1122 affects its antileishmanial activity, L-CK1.2 kinase inhibition, and safety profile. GP2A 2024, Aug 2024, Coimbra, Portugal. ⟨hal-04708945⟩
Novel Thiazole-Fused [4,5-g] or [5,4-g]Quinazolin-8-ones and Their Quinazoline Analogues: Synthesis and Biological Evaluation
Nathan Broudic, Alexandra Pacheco-Benichou, Cecile Corbiere, Blandine Baratte, Thomas Robert, et al.. Novel Thiazole-Fused [4,5-g] or [5,4-g]Quinazolin-8-ones and Their Quinazoline Analogues: Synthesis and Biological Evaluation. Pharmaceuticals, 2024, 17 (11), pp.1452. ⟨10.3390/ph17111452⟩. ⟨hal-04783236⟩