https://www.sb-roscoff.fr/fr/2020/07/06/phd-position-subject-hydration-state-rbcs-important-parameter-ensures-functions-cell-blood-flow
Introduction: 
International Training Network EVIDENCE PhD proposal - ESR 6
Paragraphes: 

EVIDENCE (https://evidence.eurice.eu/) is a consortium of 12 European partners, granted by the EU in the frame of the MARIE SKŁODOWSKA-CURIE ACTIONS - Innovative Training Networks (ITN), whose objective is to explore the properties and behaviour of RBCs under flow conditions and in vivo to understand pathophysiology and to design novel diagnostic devices. The project includes 15 PhD grants, distributed among the 12 Partners. The grant ESR6 will be based in Roscoff, France, at the Station Biologique which is an institute belonging to the CNRS and Sorbonne University.

Funding:

The EVIDENCE ITN is an EU funded international consortium of academic research centres, diagnostic labs, blood supply centres, and small companies that combines basic and translational research to improve diagnostic and therapeutic approaches on erythrocytes and during erythropoiesis. More detailsabout the consortium can be found at the EVIDENCE website https://evidence.eurice.eu/.

The MSC ITN programme offers highly competitive and attractive salary. The successful candidate will receive a salary in accordance with the regulations for MSC Fellows/early stage researchers (ESRs).
Exact salary will be confirmed upon appointment but will involve a generous Living Allowance and monthly mobility allowance depending on the successful candidate’s personal family situation.
This PhD position will likely provide experience of erythroid culture, molecular and cell biology, imaging, flow cytometry, microfluidics and electrophysiology. In addition to their individual scientific projects, all fellows benefit from further continuing education, which includes internships and secondments, a variety of training modules as well as transferable skills courses and active participation in workshops and conferences.

SUBJECT: THE HYDRATION STATE OF RBCS AS AN IMPORTANT PARAMETER THAT ENSURES THE FUNCTIONS OF THE CELL IN THE BLOOD FLOW

Document(s)

This project will aim at understanding the functions of ion channels within the RBC membrane, particularly in the context of RBC circulation and end of life. It will rely on a diversity of techniques and approaches (from the diversity of channel expression in progenitors to their involvement in aging and deformability tests) and also include RBC membrane permeability modelling to decipher the involvement of ion channels at these crucial life steps. It will bring implications useful for a better comprehension of pathologies linked to cation permeability, for storage lesions and for the production of cultured RBCs in Bioreactors.

 

Location : Roscoff Biological Station, FRANCE

UMR8227 LBI2M

CNRS – Sorbonne University

Contact : Dr Stéphane Egée (egee@sb-roscoff.fr)

Starting date : Nov-Dec 2020

Texte du contenu: 

This project will aim at understanding the functions of ion channels within the RBC membrane, particularly in the context of RBC circulation and end of life. It will rely on a diversity of techniques and approaches (from the diversity of channel expression in progenitors to their involvement in aging and deformability tests) and also include RBC membrane permeability modelling to decipher the involvement of ion channels at these crucial life steps. It will bring implications useful for a better comprehension of pathologies linked to cation permeability, for storage lesions and for the production of cultured RBCs in Bioreactors.