01/01/2018
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Journal of Molecular Structure , 2018 , 1157 , pp. 276-287
S. Hamza-Reguig
G. Bentabed-Ababsa
L.R. Domingo
M. Ríos-Gutiérrez
S. Philippot
S. Fontanay
R.E. Duval
S. Ruchaud
S. Bach
T. Roisnel
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18/09/2017
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SYNTHESIS , 2017 , 49 (19) , pp. 4500 - 4516
Florence Mongin
Rim Amara
Ghenia Bentabed-Ababsa
Madani Hedidi
Joseph Khoury
Hacan Awad
Ekhlass Nassar
Thierry Roisnel
Vincent Dorcet
Floris Chevallier
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Screening for Protein-Protein Interaction Inhibitors Using a Bioluminescence Resonance Energy Transfer (BRET)-Based Assay in Yeast
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Caroline Corbel
Sara Sartini
Elisabetta Levati
Pierre Colas
Laurent Maillet
Cyril Couturier
Barbara Montanini
Stéphane Bach
01/01/2017
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Bioactive Metabolites from the Deep Subseafloor Fungus Oidiodendron griseum UBOCC-A-114129
Marine drugs , 2017 , 15
Marion Navarri
Camille Jégou
Arnaud Bondon
Sandrine Pottier
Stéphane Bach
Blandine Baratte
Sandrine Ruchaud
Georges Barbier
Gaëtan Burgaud
Yannick Fleury
01/01/2017
Article
Fused Systems Based on 2-Aminopyrimidines: Synthesis Combining Deprotolithiation-in situ Zincation with N -Arylation Reactions and Biological Properties
European Journal of Organic Chemistry , 2017 , 2017 (39) , pp. 5903-5915
Madani Hedidi
Julien Maillard
William Erb
Frédéric Lassagne
Yury Halauko
Oleg Ivashkevich
Vadim Matulis
Thierry Roisnel
Vincent Dorcet
Monzer Hamze
et al.
01/01/2017
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Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases
Marine Drugs , 2017 , 15
Nadège Loaëc
Eletta Attanasio
Benoît Villiers
Emilie Durieu
Tania Tahtouh
Morgane Cam
Rohan A. Davis
Aline Alencar
Mélanie Roué
Marie-Lise Bourguet-Kondracki
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01/01/2017
Article
Sibiriline, a new small chemical inhibitor of receptor-interacting protein kinase 1, prevents immune-dependent hepatitis
FEBS Journal , 2017 , 284 (18) , pp. 3050-3068
F. Le Cann
C. Delehouzé
S. Leverrier-Penna
A. Filliol
A. Comte
O. Delalande
N. Desban
B. Baratte
I. Gallais
C. Piquet-Pellorce
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01/01/2017
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6E11, a highly selective inhibitor of Receptor-Interacting Protein Kinase 1, protects cells against cold hypoxia-reoxygenation injury
Scientific Reports , 2017 , 7 (1) , pp. 12931
C. Delehouzé
S. Leverrier-Penna
F. Le Cann
A. Comte
M. Jacquard-Fevai
O. Delalande
N. Desban
B. Baratte
I. Gallais
F. Faurez
et al.
16/09/2016
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From Peptide Aptamers to Inhibitors of FUR, Bacterial Transcriptional Regulator of Iron Homeostasis and Virulence
ACS Chemical Biology , 2016 , 11 (9) , pp. 2519-2528
Sophie Mathieu
Cheickna Cisse
Sylvie Vitale
Aynur Ahmadova
Mélissa Degardin
Julien Perard
Pierre Colas
Roger Miras
Didier Boturyn
Jacques Covès
et al.
01/03/2016
Article
Novel optimization of valmerins (tetrahydropyrido[1,2-a]isoindolones) as potent dual CDK5/GSK3 inhibitors
European Journal of Medicinal Chemistry , 2016 , 115 , pp. 311--325
Aziz Ouach
Rajâa Boulahjar
Christine Vala
Stéphane Bourg
Pascal Bonnet
Christiane Guguen-Guillouzo
Myriam Ravache
Rémy Le Guevel
Olivier Lozach
Saïd Lazar
et al.
01/01/2016
Article
Synthesis of N-pyridyl azoles using a deprotometalation-iodolysis-N-arylation sequence and evaluation of their antiproliferative activity in melanoma cells
Tetrahedron , 2016 , 72 , pp. 6467--6476
M. Hedidi
W. Erb
G. Bentabed-Ababsa
F. Chevallier
L. Picot
V. Thiéry
S. Bach
S. Ruchaud
T. Roisnel
V. Dorcet
et al.
01/01/2016
Article
Microwave synthesis of new 3-(3-aminopropyl)-5-arylidene-2-thioxo-1,3-thiazolidine-4-ones as potential Ser/Thr protein kinase inhibitors
Medicinal Chemistry Research , 2016 , 25 (12) , pp. 2940--2958
Camille Déliko Dago
Wacothon Karime Coulibaly
Yves-Alain Bekro
Janat A. Mamyrbekova-Bekro
Beatrice Foll-Josselin
Audrey Defontaine
Claire Delehouze
Stéphane Bach
Sandrine Ruchaud
Rémy Le Guével
et al.
01/01/2016
Article
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Antimicrobial Agents and Chemotherapy , 2016
Emilie Durieu
Eric Prina
Olivier Leclercq
Nassima Oumata
Nicolas Gaboriaud-Kolar
Konstantina Vougogiannopoulou
Nathalie Aulner
Audrey Defontaine
Joo Hwan No
Sandrine Ruchaud
et al.
01/01/2016
Article
Marine Natural Products from New Caledonia—A Review
Marine drugs , 2016 , 14 (3) , pp. 58
Sofia-Eléna Motuhi
Mohamed Mehiri
Claude Elisabeth Payri
Stéphane La Barre
Stéphane Bach
30/09/2015
Article
Azine and Diazine Functionalization Using 2,2,6,6-Tetramethylpiperidino-Based Lithium–Metal Combinations: Application to the Synthesis of 5,9-Disubstituted Pyrido[3′,2′:4,5]pyrrolo[1,2-c]pyrimidines
SYNLETT , 2015
Nada Marquise
Nguyen Tan Tai
Floris Chevallier
Laurent Picot
Valérie Thiéry
Lozach Olivier
Stéphane Bach
Sandrine Ruchaud
Mongin Florence
01/01/2015
Article
Advances in tetrahydropyrido[1,2-a]isoindolone (valmerins) series: Potent glycogen synthase kinase 3 and cyclin dependent kinase 5 inhibitors.
European Journal of Medicinal Chemistry , 2015 , 101 , pp. 274-287
Rajâa Boulahjar
Aziz Ouach
Stéphane Bourg
Pascal Bonnet
Olivier Lozach
Laurent Meijer
Christiane Guguen-Guillouzo
Rémy Le Guevel
Saïd Lazar
Mohamed Akssira
et al.
01/01/2015
Article
Synthesis and molecular modelling studies of 8-arylpyrido[3',2':4,5thieno[3,2-d]pyrimidin-4-amines as multitarget Ser/Thr kinases inhibitors
European Journal of Medicinal Chemistry , 2015 , 92 , pp. 124-134
Yvonnick Loidreau
Emmanuel Deau
Pascal Marchand
Marie-Renée Nourrisson
Cédric Logé
Gael Coadou
Nadège Loaëc
Laurent Meijer
Thierry Besson
01/01/2015
Article
Synthetic Development of New 3-(4-Arylmethylamino)butyl-5-arylidene-rhodanines under Microwave Irradiation and Their Effects on Tumor Cell Lines and against Protein Kinases
Molecules , 2015 , 20 (7) , pp. 12412-12435
Camille Déliko Dago
Christelle Ambeu
Wacothon-Karime Coulibaly
Yves-Alain Békro
Janat Mamyrbékova
Audrey Defontaine
Blandine Baratte
Stéphane Bach
Sandrine Ruchaud
Rémy Le Guével
et al.
01/01/2015
Article
Azine and Diazine Functionalization Using 2,2,6,6-Tetramethylpiperidino-Based Lithium-Metal Combinations: Application to the Synthesis of 5,9-Disubstituted Pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidines
SYNLETT , 2015 , pp. Ahead of Print
Nada Marquise
Tan Tai Nguyen
Floris Chevallier
Laurent Picot
Valérie Thiéry
Olivier Lozach
Stéphane Bach
Sandrine Ruchaud
Florence Mongin
01/11/2014
Article
Synthesis of new pyridazino[4,5-b]indol-4-ones and pyridazin-3(2H)-one analogs as DYRK1A inhibitors
Bioorganic and Medicinal Chemistry Letters , 2014 , 24 (21) , pp. 5037 - 5040
Amélie Bruel
Romain Bénéteau
Mylène Chabanne
Olivier Lozach
Rémy Le Guevel
Myriam Ravache
Hélène Bénédetti
Laurent Meijer
Cédric Logé
Jean-Michel Robert
31/10/2014
Article
Impact of meriolins, a new class of cyclin-dependent kinase inhibitors, on malignant glioma proliferation and neo-angiogenesis.
Neuro-Oncology , 2014 , 16 (11) , pp. 1484-98
Marie Jarry
Céline Lecointre
Céline Malleval
Laurence Desrues
Marie-Thérèse Schouft
Vadim Lejoncour
François Liger
Gildas Lyvinec
Benoît Joseph
Nadège Loaëc
et al.
18/08/2014
Article
9- and 11-substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma.
European Journal of Medicinal Chemistry , 2014 , 83 , pp. 274-83
Franziska Maiwald
Diego Benítez
Diego Charquero
Mahin Abad Dar
Hanna Erdmann
Lutz Preu
Oliver Koch
Christoph Hölscher
Nadège Loaëc
Laurent Meijer
et al.
18/08/2014
Article
Synthesis and biological evaluation of tetrahydro[1,4]diazepino[1,2-a]indol-1-ones as cyclin-dependent kinase inhibitors.
European Journal of Medicinal Chemistry , 2014 , 83 , pp. 617-629
A. Putey
G. Fournet
O. Lozach
L. Perrin
L. Meijer
B. Joseph
01/05/2014
Article
Acridone Alkaloids from Glycosmis chlorosperma as DYRK1A Inhibitors
Journal of Natural Products , 2014 , 77 (5) , pp. 1117-1122
Mehdi A. Beniddir
Erell Le Borgne
Bogdan I. Iorga
Nadège Loaëc
Olivier Lozach
Laurent Meijer
Khalijah Awang
Marc Litaudon
01/05/2014
Article
New 5-ylidene rhodanine derivatives based on the dispacamide A model.
Molecular Diversity , 2014 , 18 (2) , pp. 375-88
Solène Guihéneuf
Ludovic Paquin
François Carreaux
Emilie Durieu
Thierry Roisnel
Laurent Meijer
Jean-Pierre Bazureau
01/03/2014
Article
cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease.
Molecular Pharmacology , 2014 , 85 (3) , pp. 441-50
Xavier Fant
Emilie Durieu
Gaëtan Chicanne
Bernard Payrastre
Diego Sbrissa
Assia Shisheva
Emmanuelle Limanton
François Carreaux
Jean-Pierre Bazureau
Laurent Meijer
01/01/2014
Article
Synthesis and biological evaluation of tetrahydro[1,4]diazepino[1,2-a]indol-1-ones as cyclin-dependent kinase inhibitors
European Journal of Medicinal Chemistry , 2014 , 83 , pp. 617-629
Putey Aurelien
Fournet Guy
Olivier Lozach
Perrin Lionel
Meijer Laurent
Joseph Benoît
01/01/2014
Article
Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection
Antimicrobial Agents and Chemotherapy , 2014 , 58 (3) , pp. 1501-1515
Najma Rachidi
Jean François Taly
Emilie Durieu
Olivier Leclercq
Nathalie Aulner
Eric Prina
Pascale Pescher
Cedric Notredame
Laurent Meijer
Gerald F Späth
30/11/2013
Article
Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part I.
Molecules , 2013 , 19 (10) , pp. 15546-71
Alicia Foucourt
Damien Hédou
Carole Dubouilh-Benard
Laurent Désiré
Anne-Sophie Casagrande
Bertrand Leblond
Nadège Loäec
Laurent Meijer
Thierry Besson
01/01/2012
Article
Novel Tetrahydropyrido[1,2-a]isoindolone Derivatives (Valmerins): Potent Cyclin-Dependent Kinase/Glycogen Synthase Kinase 3 Inhibitors with Antiproliferative Activities and Antitumor Effects in Human Tumor Xenografts
Journal of Medicinal Chemistry , 2012 , 55 , pp. 9589-9606
Rajâa Boulahjar
Aziz Ouach
Chiurato Matteo
Stéphane Bourg
Myriam Ravache
Rémy Le Guével
Séverine Marionneau
Thibauld Oullier
Olivier Lozach
Laurent Meijer
et al.
01/01/2012
Article
The Plasmodium falciparum, Nima-related kinase Pfnek-4: a marker for asexual parasites committed to sexual differentiation.
Malaria Journal , 2012 , 11 (1) , pp. 250
Luc Reininger
Miguel Garcia
Andrew Tomlins
Sylke Müller
Christian Doerig
01/12/2005
Article
Synthesis and evaluation of the antiproliferative activity of novel thiazoloquinazolinone kinases inhibitors.
Journal of Enzyme Inhibition and Medicinal Chemistry , 2005 , 20 (6) , pp. 557-68
Alexandra Testard
Laurent Picot
Olivier Lozach
Melina Blairvacq
Laurent Meijer
Laurence Murillo
Jean-Marie Piot
Valérie Thiéry
Thierry Besson
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