Cadre de recherche IFREMER

Senior researcher

Directrice de recherche (C3 Ifremer)

Degrees

  • Ph. D. thesis, Université Claude Bernard de Lyon: « Epstein Barr virus (EBV) latency and reactivation, the key role of EB1 transregulator ». 1995
  • HDR thesis, University Jussieu of Paris: «  Vibrio splendidus : biodiversity, virulence and genome plasticity » 2004

Research

  • 1991-1995: PhD at "Ecole Normale Superieure", Lyon, France.

     - Research project: "Epstein Barr Virus (EBV) latency and reactivation, the key role of EB1 trans-regulator".
     - Principal Investigators (PI): Dr Alain Sergeant and Dr Laura Corbo.
 

  • 1996-1998 : Post-doctoral position et the Institut Gustave Roussy, CNRS,  Villejuif, France
         - Research project: Carcinoma and Epstein Barr virus.
         - PI: Dr Irene Joab.
     
  • 1998-2000 : Post-doctoral position at the French Insitiute for marine science (IFREMER); La Tremblade; France
         - Research project: Molecular taxonomy of Marteilia, a parasite for Ostrea edulis.
         - PI: Dr Franck Berthe and Dr Manolo Gouy.
     
  • 2000-2004 : Permanent position at the French Institute for marine science (Ifremer), "Laboratoire de génétique et Pathologie", La Tremblade, France ;
         - Research project: Vibrio, taxonomy and virulence.
         - Head of the vibrio team.
     
  • 2004-2008 : Invited scientist in the "Unité de Plasticité du Génome Bactérien" at the Pasteur Institute, Paris.
         - Research project: Vibrio splendidus, genomic and genetic.
         - PI: Dr Didier Mazel.
     
  • 2008-2010: Invited Scientist at Harvard Medical School, Boston.
         - Research project Vibrio nigripulchritudo, LGT and virulence.
         - PI: Pr Matt Waldor.
     
  • Since September 2010: Principal investigator of the Vibrio team at the Station Biologique de Roscoff

 

Scientific interest

My research interests are focused on investigating the molecular mechanisms involved in the emergence of vibrio pathogenesis of marine invertebrates. These include molecular epidemiology with emphasis on biodiversity, virulence and genome plasticity, environmental genomics and host/pathogens interactions. My lab has shown strong technical competence in genomic and genetic developments over the last decade, whilst investigation several vibrio species isolated from osyters, shrimps and corals.

Member of the editorial borad of Environmental Microbiology (since 2015).
Member of the ANR evalution commitee (2006-2015).

 

Publications

1- Piel D, Bruto M, James A, Labreuche Y, Lambert C, Janicot A, Chenivesse S, Petton B, Wegner KM, Stoudmann C, Blokesch M, Le Roux F. Selection of Vibrio crassostreae relies on a plasmid expressing a type 6 secretion system cytotoxic for host immune cells. Environ Microbiol. 2019 Aug 7. doi: 10.1111/1462-2920

2- Rubio T, Oyanedel-Trigo D, Labreuche Y, Toulza E, Luo X, Bruto M, Chaparro C, Torres Bejar M, de Lorgeril J, Haffner P, Vidal-Dupiol J, Lagorce A, Petton B, Mitta G, Jacq A, Le Roux F*, Charrière G* and Destoumieux-Garzón D1*. Species-specific mechanisms of cytotoxicity towards immune cells determine the successful outcome of Vibrio infections. Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14238-14247.(*co-correspondence)

3- Bruto M, Labreuche Y, James A, Piel D, Chenivesse S, Petton B, Polz MF, Le Roux F. Ancestral gene acquisition as the key to virulence potential in environmental Vibrio populations. ISME J. 2018 Dec;12(12):2954-2966. 

4- Parizadeh L, Tourbiez D, Garcia C, Haffner P, Dégremont L, Le Roux F*, Travers MA*.Ecologically realistic model of infection for exploring the host damage caused by Vibrio aestuarianus. Environ Microbiol. 2018 20(12):4343-4355. (*co-correspondence)

5- Labreuche Y, Chenivesse S, Jeudy A, Le Panse S, Boulo V, Ansquer D, Pagès S, Givaudan A, Czjzek M, Le Roux F. Nigritoxin is a bacterial toxin for crustaceans and insects. Nat Commun. 2017 Nov 1;8(1):1248. 

6- Bruto M, James A, Petton B, Labreuche Y, Chenivesse S, Alunno-Bruscia M, Polz MF, Le Roux F. Vibrio crassostreae, a benign oyster colonizer turned into a pathogen after plasmid acquisition. ISME J. 2017 Apr;11(4):1043-1052.

7- Le Roux F, Wegner KM, Polz MF. Oysters and Vibrios as a Model for Disease Dynamics in Wild Animals. Trends Microbiol. 2016 Jul;24(7):568-80. (review)

8- Lemire A, Goudenège D, Versigny T, Petton B, Calteau A, Labreuche Y, Le Roux F.Populations, not clones, are the unit of vibrio pathogenesis in naturally infected oysters. ISME J. 2015 Jul;9(7):1523-31.

9- Goudenège D, Travers MA, Lemire A, Petton B, Haffner P, Labreuche Y, Tourbiez D, Mangenot S, Calteau A, Mazel D, Nicolas JL, Jacq A, Le Roux F. A single regulatory gene is sufficient to alter Vibrio aestuarianus pathogenicity in oysters. Environ Microbiol. 2015 Nov;17(11):4189-99.

10- Goudenège D, Labreuche Y, Krin E, Ansquer D, Mangenot S, Calteau A, Médigue C, Mazel D, Polz MF, Le Roux F. Comparative genomics of pathogenic lineages of Vibrio nigripulchritudo identifies virulence-associated traits. ISME J. 2013 Oct;7(10):1985-96.