Created 12/06/2020

The Le Roux team at the Department of Integrative Biology of Marine Models, Marine station of Sorbonne University (Roscoff, France), is recruiting postdoctoral fellow to study key ecological and evolutionary processes underlying phage-bacteria dynamics in nature, with potential applications for phage therapy in aquaculture. An oyster bacterial pathogen, Vibrio crassostreae and its infecting phages will be used as model system to investigate the molecular bases and evolution of phage infections in oyster farms.

The Le Roux team seeks to understand the evolution of microbial populations in the wild and their adaptation to the environment. To this aim they develop an integrated approach (from ecology to the gene, from mathematical modeling to genetic) to understand the evolution and adaptation of bacterial pathogens (the Vibrionaceae) threatening animal species (e.g. the oyster Crassostreae gigas) that are a major importance for both environmental and socio-economic reasons. Given the abundance of phages, their potential impact on bacterial selection and potential applications for phage therapy in aquaculture, the team initiates a new research project to understand the co-evolutionary processes underlying interactions between bacteria and phages.

References

1- Bruto M, Labreuche Y, James A, Piel D, Chenivesse S, Petton B, Polz MF, Le Roux F. Ancestral gene acquisition as the key to virulence potential in environmental Vibrio populations. ISME J. 2018 Dec;12(12):2954-2966.

2- Labreuche Y, Chenivesse S, Jeudy A, Le Panse S, Boulo V, Ansquer D, Pagès S, Givaudan A, Czjzek M, Le Roux F. Nigritoxin is a bacterial toxin for crustaceans and insects. Nat Commun. 2017 Nov 1;8(1):1248.

3- Bruto M, James A, Petton B, Labreuche Y, Chenivesse S, Alunno-Bruscia M, Polz MF, Le Roux F. Vibrio crassostreae, a benign oyster colonizer turned into a pathogen after plasmid acquisition. ISME J. 2017 Apr;11(4):1043-1052.

4- Lemire A, Goudenège D, Versigny T, Petton B, Calteau A, Labreuche Y, Le Roux F. Populations, not clones, are the unit of vibrio pathogenesis in naturally infected oysters. ISME J. 2015 Jul;9(7):1523-31.

Appointment and benefit.

The postdoctoral fellow will begin the 1st April 2021 for a maximum of three years, and be funded by the ERC-2020-DYNAMIC.

Job description.

We are looking for an enthusiastic and motivated scientist in environmental microbiology with excellent skill in statistics and good background in ecology and evolution. The post doc will be in charged of a specific aim of the DYNAMIC project, which is to understand the co-evolutionary processes underlying interactions between bacteria and phages in nature. The successful candidate will be in charge of i) time-series of consecutive sampling of a French Atlantic coastal zone site (July-August 2021; July 22, 23); ii) isolation and storage of phage and vibrio isolates, cross infection assays; iii) time shift and local adaptation analysis; iv) metagenomic analyses of phages dynamic.

He/she will work in close collaboration with other members of the lab (field, experimental and in silico work). Statistic analysis involves short stays in the laboratory of our collaborator Sylvain Gandon (CEFE, CNRS Montpellier).

Successful candidate must have high degree of independence and real abilities to work in synergy with other people from the team (technician, biocomputist, students). In addition to our collaborative network, complementarity and cohesion are a fundamental element of the strength of our team.

Eligibility criteria.

To apply for the position, candidates must hold an internationally-recognized PhD degree in Microbiology. Excellent written and spoken English is a requirement for the position. Application should include: i) a Curriculum Vitae; ii) the description of your past achievements (max. 1 page); iii) At least two letters of references.

Selection process.

A first selection will be based on CV, past achievements and references letter. A second selection will be based on an interview with F. Le Roux and collaborators.