Understanding the ecological and evolutionary dynamics of infectious agents is important for diagnosing, predicting and preventing diseases in farmed and wild species. During his PhD, Damien studied the evolution of V. crassostreae virulence in relation to the oyster as a host and to the phages as predators. He identified molecular mechanisms leading to the adaptation of vibrios to oysters. He demonstrated the emergence of virulent strains of V. crassostreae in an area impacted by the juvenile oyster mortality syndrome. The emergence of more virulent V. crassostreae strains is linked to the acquisition of a plasmid encoding a type 6 secretion system responsible for lethal activity towards oyster hemocytes. He is, now, working as a research engineer to study mechanistic bases of phage-host interactions using V. crassostreae and its virulent phages.
EMPLOYMENT AND EDUCATION
2020: Research engineer, Genomic of Vibrio team, Marine Station of Roscoff, France.
2016-2019: PhD, Genomic of Vibrio team, Marine Station of Roscoff, France. Evolution of virulence of Vibrio crassostreae in relation to oysters as hosts and phages as predators
2014-2016: Master degree, cellular and molecular infection, vaccinology and therapeutic antibodies at the University François Rabelais of Tours, France
Master I internship (2 months), Insect Biology Institute, Tours, France. Role of virus-like particles, produced by an endoparasitic wasp Venturia canescens, in its host Ephestia kuehniella (PI: Dr Jean Michel Drezen)
Master II internship (6 months), Spirochetes team, Pasteur Institute, Paris, France. Distribution and functionality of the CRISPR / Cas system in leptospires (PI: Dr Mathieu Picardeau)