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Scientist of Ifremer

Directrice de recherche (C3 Ifremer)

Degrees

  • Ph. D. thesis, Université Claude Bernard de Lyon: « Epstein Barr virus (EBV) latency and reactivation, the key role of EB1 transregulator ». 1995
  • HDR thesis, University Jussieu of Paris: «  Vibrio splendidus : biodiversity, virulence and genome plasticity » 2004

Research

  • 1991-1995: PhD at "Ecole Normale Superieure", Lyon, France.

     - Research project: "Epstein Barr Virus (EBV) latency and reactivation, the key role of EB1 trans-regulator".
     - Principal Investigators (PI): Dr Alain Sergeant and Dr Laura Corbo.
 

  • 1996-1998 : Post-doctoral position et the Institut Gustave Roussy, CNRS,  Villejuif, France
         - Research project: Carcinoma and Epstein Barr virus.
         - PI: Dr Irene Joab.
     
  • 1998-2000 : Post-doctoral position at the French Insitiute for marine science (IFREMER); La Tremblade; France
         - Research project: Molecular taxonomy of Marteilia, a parasite for Ostrea edulis.
         - PI: Dr Franck Berthe and Dr Manolo Gouy.
     
  • 2000-2004 : Permanent position at the French Institute for marine science (Ifremer), "Laboratoire de génétique et Pathologie", La Tremblade, France ;
         - Research project: Vibrio, taxonomy and virulence.
         - Head of the vibrio team.
     
  • 2004-2008 : Invited scientist in the "Unité de Plasticité du Génome Bactérien" at the Pasteur Institute, Paris.
         - Research project: Vibrio splendidus, genomic and genetic.
         - PI: Dr Didier Mazel.
     
  • 2008-2010: Invited Scientist at Harvard Medical School, Boston.
         - Research project Vibrio nigripulchritudo, LGT and virulence.
         - PI: Pr Matt Waldor.
     
  • Since September 2010: Principal investigator of the Vibrio team at the Station Biologique de Roscoff

 

Scientific interest

My research interests are focused on investigating the molecular mechanisms involved in the emergence of vibrio pathogenesis of marine invertebrates. These include molecular epidemiology with emphasis on biodiversity, virulence and genome plasticity, environmental genomics and host/pathogens interactions. My lab has shown strong technical competence in genomic and genetic developments over the last decade, whilst investigation several vibrio species isolated from osyters, shrimps and corals.

Member of the editorial borad of Environmental Microbiology (since 2015).
Member of the ANR evalution commitee (2006-2015).

 

Publications

 

1-     Bruto M, James A, Petton B, Labreuche Y, Chenivesse S, Alunno-Bruscia M, Polz MF, Le Roux FVibrio crassostreae, a benign oyster colonizer turned into a pathogen after plasmid acquisition. ISME J. 2016. (IF: 9.328)

2-     Le Roux F. Environmental vibrios : «a walk on the wild side ». Environ Microbiol report, Crystal ball. 2016 Nov 29. doi: 10.1111/1758-2229.12497.IF : 3.5)

3-     Foulon V, Le Roux F, Lambert C, Huvet A, Soudant P, Paul-Pont I. Colonization of Polystyrene Microparticles by Vibrio crassostreae: Light and Electron Microscopic Investigation. Environ Sci Technol. 2016 Oct 6. (IF: 5.393)

4-     Le Roux F, Wegner KM, Polz MF. Oysters and Vibrios as a Model for Disease Dynamics in Wild Animals. Trends Microbiol. 2016 Jul;24(7):568-80. (IF: 9.186)

5-     Le Roux F. Diagnosis of vibriosis in the era of genomics: lessons from invertebrates. Rev Sci Tech. 2016 Apr;35(1):259-69. 

6-     Vanhove AS, Rubio TP, Nguyen AN, Lemire A, Roche D, Nicod J, Vergnes A, Poirier AC, Disconzi E, Bachère E, Le Roux F, Jacq A, Charrière GM, Destoumieux-Garzón D. Copper homeostasis at the host vibrio interface: lessons from intracellular vibrio transcriptomics. Environ Microbiol. 2016 Mar;18(3):875-88. (IF: 5.932)

7-     Le Roux F, Wegner KM, Baker-Austin C, Vezzulli L, Osorio CR, Amaro C, Ritchie JM, Defoirdt T, Destoumieux-Garzón D, Blokesch M, Mazel D, Jacq A, Cava F, Gram L, Wendling CC, Strauch E, Kirschner A, Huehn S. The emergence of Vibrio pathogens in Europe: ecology, evolution, and pathogenesis (Paris, 11-12th March 2015). Front Microbiol. 2015 Aug 13;6:830. (IF: 4.165)

8-     Petton B, Bruto M, James A, Labreuche Y, Alunno-Bruscia M, Le Roux F. Crassostrea gigas mortality in France: the usual suspect, a herpes virus, may not be the killer in this polymicrobial opportunistic disease. Front Microbiol. 2015 Jul 6;6:686. (IF: 4.165)

9-     Iqbal N, Guérout AM, Krin E, Le Roux F, Mazel D. Comprehensive functional analysis of the eighteen Vibrio cholerae N16961 toxin-antitoxin systems substantiates their role in stabilizing the superintegron. J Bacteriol. 2015 Jul;197(13):2150-9. (IF : 3.586)

10-  Lemire A, Goudenège D, Versigny T, Petton B, Calteau A, Labreuche Y, Le Roux F. Populations, not clones, are the unit of vibrio pathogenesis in naturally infected oysters. ISME J. 2015 Jul;9(7):1523-31. (IF: 9.328)

11-  Goudenège D, Travers MA, Lemire A, Petton B, Haffner P, Labreuche Y, Tourbiez D, Mangenot S, Calteau A, Mazel D, Nicolas JL, Jacq A, Le Roux F. A single regulatory gene is sufficient to alter Vibrio aestuarianuspathogenicity in oysters. Environ Microbiol. 2015 Nov;17(11):4189-99. (IF: 5.932)

12-  Vanhove AS, Duperthuy M, Charrière GM, Le Roux F, Goudenège D, Gourbal B, Kieffer-Jaquinod S, Couté Y, Wai SN, Destoumieux-Garzón D. Outer membrane vesicles are vehicles for the delivery of Vibrio tasmaniensis virulence factors to oyster immune cells. Environ Microbiol. 2015 Apr;17(4):1152-6. (IF: 5.932)

13-  Goudenège D, Boursicot V, Versigny T, Bonnetot S, Ratiskol J, Sinquin C, LaPointe G, Le Roux F, Delbarre-Ladrat C. Genome sequence of Vibrio diabolicus and identification of the exopolysaccharide HE800 biosynthesis locus. Appl Microbiol Biotechnol. 2014 Dec;98(24):10165-76. (IF : 3.376).

14-  Goudenège D, Labreuche Y, Krin E, Ansquer D, Mangenot S, Calteau A, Médigue C, Mazel D, Polz MF, Le Roux F. Comparative genomics of pathogenic lineages of Vibrio nigripulchritudo identifies virulence-associated traits. ISME J. 2013 Oct;7(10):1985-96. (IF: 9.328).

15-  Cordero OX, Wildschutte H, Kirkup B, Proehl S, Ngo L, Hussain F, Le Roux F, Mincer T, Polz MF. Ecological populations of bacteria act as socially cohesive units of antibiotic production and resistance. Science. 2012 Sep 7; 337(6099): 1228-31. (IF: 33.61).

16-  Labreuche Y, Pallandre L, Ansquer D, Herlin J, Wapotro B, Le Roux F. Pathotyping of Vibrio isolates by multiplex PCR reveals a risk of virulent strain spreading in New Caledonian shrimp farms. Microb Ecol. 2012 Jan; 63(1):127-38. (IF: 3.232).

17-  Santos Ede O, Alves N Jr, Dias GM, Mazotto AM, Vermelho A, Vora GJ, Wilson B, Beltran VH, Bourne DG, Le Roux F, Thompson FL. Genomic and proteomic analyses of the coral pathogen Vibrio coralliilyticus reveal a diverse virulence repertoire. ISME J. 2011 Sep; 5(9):1471-83. (IF: 9.328). 

18-  Duperthuy M, Schmitt P, Garzón E, Caro A, Rosa RD, Le Roux F, Lautrédou-Audouy N, Got P, Romestand B, de Lorgeril J, Kieffer-Jaquinod S, Bachère E, Destoumieux-Garzón D. Use of OmpU porins for attachment and invasion of Crassostrea gigas immune cells by the oyster pathogen Vibrio splendidus. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7): 2993-8. (IF: 9.423)

19-  Le Roux F, Labreuche Y, Davis BM, Iqbal N, Mangenot S, Goarant C, Mazel D, Waldor MK. Virulence of an emerging pathogenic lineage of Vibrio nigripulchritudo is dependent on two plasmids. Environ Microbiol. 2011 Feb; 13(2): 296-306. (IF: 5.932)

20-  Le Roux F, Davis BM, Waldor MK. Conserved small RNAs govern replication and incompatibility of a diverse new plasmid family from marine bacteria. Nucleic Acids Res. 2011 Feb;39(3):1004-13. (IF: 9.202).